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Cat. No.: HY-19938

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MTL-005

MTL-005 is a boron-containing radiosensitizer used in Boron Neutron Capture Therapy (BNCT). MTL-005 enriches the boron-10 isotope in tumor tissues, causing nuclear fission under thermal neutron irradiation, releasing high linear energy transfer (LET) α particles and lithium ions, which selectively destroy tumor cells while minimizing damage to surrounding normal tissues. MTL-005 significantly controlls the tumor progression in the SCCVII squamous cell carcinoma mouse model and prolonged the survival of the mice. MTL-005 can be used to study solid tumors such as head and neck cancer.

For research use only. We do not sell to patients.

CAS No.: 1030303-53-7
Formula: C₃₈H₄₂B₂₀CuN₆O₆
Molecular Weight:958.54

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (277 KB)

MTL-005 Chemical Structure

CAS No.: 1030303-53-7

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity

Description

Chemical Information

CAS No. 1030303-53-7
Molecular Weight 958.54
Formula C₃₈H₄₂B₂₀CuN₆O₆
SMILES

O=N(C1=C2[N-]3C(C=C2)=C(C4=[N]5[Cu+2]3([N]6=C1C=CC6=C7C8=CC(OCC9%10%11%12B%13%14%15([H])B9%16%17([H])B%10%18%19([H])B%11%20%21([H])C%12%13%22([H])B%14%23%24([H])B%15%16%25([H])B%18%17%26([H])B%20%19%27([H])B%21%22%23([H])B%24%25%27%26[H])=CC=C8)[N-]%28C7=CC=C%28C(N(=O)=O)=C5C=C4)C%29=CC=CC(OCC%30%31%32%33B%34%35%36([H])B%30%37%38([H])B%31%39%40([H])B%32%41%42([H])C%33%34%43([H])B%35%44%45([H])B%36%37%46([H])B%39%38%47([H])B%41%40%48([H])B%42%43%44([H])B%45%46%48%47[H])=C%29)=O
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

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Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (277 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Tahara M, et al. Cisplatin/5-FU 100/1000 in Japanese Patients With Recurrent/Metastatic SCCHN: Management of Recurrent Head-and-Neck Squamous Cell Carcinoma. International Journal of Radiation Oncology, Biology, Physics. 2014 Feb 1;88(2):509-10.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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