Anticancer agent 151
Anticancer agent 151 (compound 6C) is an anticancer agent. Anticancer agent 151 exhibits excellent in vitro cytotoxic activity against MCF-7 cells with an IC50 value of 6.3 μM.
For research use only. We do not sell to patients.
- CAS No.: 1227476-97-2
- Formula: C22H18Cl2N2O3
- Molecular Weight:429.30
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Biological Activity
Description
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| K562 | IC50 |
>10 μM
Compound: 6c
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Cytotoxicity against human K562 cells after 72 hrs by calcein-AM assay
Cytotoxicity against human K562 cells after 72 hrs by calcein-AM assay
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[PMID: 23981532] |
| MCF7 | IC50 |
7.9 μM
Compound: 6c
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Cytotoxicity against human MCF7 cells after 72 hrs by calcein-AM assay
Cytotoxicity against human MCF7 cells after 72 hrs by calcein-AM assay
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[PMID: 23981532] |
Chemical Information
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CAS No. 1227476-97-2
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Molecular Weight 429.30
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Formula C22H18Cl2N2O3
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SMILES
O=C(C1=C(C=CC(Cl)=C1)O)N[C@H](C(NC2=CC=C(C=C2)Cl)=O)CC3=CC=CC=C3
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocols
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Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
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Cell Viability Determination by MTT Colorimetric Assay
The following protocol uses the MTT colorimetric assay as a classic literature-established method for assessing cell viability/metabolic activity in cultured mammalian cells. MTT[3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide] is reduced by metabolically active cells to a colored formazan product; the amount of formazan is quantified spectrophotometrically and provides an indirect measure of metabolically active viable cells. Importantly, MTT reduction reflects cellular oxidoreductase/metabolic activity rather than an absolute direct count of living cells, so changes in cellular metabolism can alter the signal independently of cell number.
Purity & Documentation
References
[1]. Imramovský A, et al. Substituted 2-hydroxy-N-(arylalkyl)benzamides induce apoptosis in cancer cell lines. Eur J Med Chem. 2013;68:253-259. [Content Brief]
[2]. Aleš Imramovský, et al. Substituted 2-hydroxy-N-(arylalkyl)benzamides induce apoptosis in cancer cell lines. Eur J Med Chem. 2013. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Anticancer agent 151 Related Classifications
HY-155167 Related Classifications
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