Linderane (Standard)
Linderane (Standard) is the analytical standard of Linderane (HY-N0688). This product is intended for research and analytical applications. Linderane is an orally active natural sesquiterpene lactone with blood-brain barrier permeability. Linderane indirectly activates PDE3 by activating ERK/STAT3, thereby inhibiting the cAMP/PKA/CREB signaling pathway and hepatic gluconeogenesis. Linderane protects pancreatic β cells against oxidative damage by inhibiting the activation of the p38 MAPK pathway and activating the Nrf2 pathway. Linderane inhibits cell apoptosis and ameliorates intestinal mucosal inflammation by suppressing the IL-6/JAK/STAT3 signaling pathway. Linderane reduces pain sensitivity and alleviates anxiety-like behaviors by activating cannabinoid receptor 2 (CB2R). Linderane can be used in studies related to type 2 diabetes, ulcerative colitis, and chronic inflammatory pain with anxiety.
For research use only. We do not sell to patients.
- CAS No.: 13476-25-0
- Formula: C15H16O4
- Molecular Weight:260.29
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Product Information
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Chemical Information
- Purity & Documentation
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Help & FAQs
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HY-N0688
LinderaneAnti-Inflammatory Agent -
HY-N0141
ParthenolideNF-κB Inhibitor -
HY-N0591
Dehydrocostus LactoneSesquiterpene -
HY-N0201
Atractylenolide ITLR4 Antagonist -
HY-N0141R
Parthenolide (Standard)NF-κB Inhibitor -
HY-N0591R
Dehydrocostus Lactone (Standard)Standard of Dehydrocostus Lactone -
HY-N0201R
Atractylenolide I (Standard)TLR4 Antagonist
Product Information
Information
Application
The compound is the grade of analytical standard, which is the reference standard supplied assay. It is commonly used in qualitative, quantitative and methodological research experiments in HPLC, GC and MS.
Chemical Information
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CAS No. 13476-25-0
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Molecular Weight 260.29
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Formula C15H16O4
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SMILES
O=C(O[C@@]1([H])C2=C3OC=C2C)C4(CC/C=C(C)\C3)[C@@H]1O4
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Linderane (Standard) Related Classifications
HY-N0688R Related Classifications
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Keywords
- Linderane (Standard)
- 13476-25-0
- Reference Standards
- ERK
- STAT
- Phosphodiesterase (PDE)
- PKA
- p38 MAPK
- Keap1-Nrf2
- JAK
- Interleukin Related
- Apoptosis
- Cannabinoid Receptor
- Extracellular signal regulated kinases
- Protein kinase A
- Janus kinase
- IL
- STAT3
- CB2R
- INS-1 pancreatic β cells
- rat primary hepatocytes
- Nrf2
- ERK1/2
- RAW264.7 macrophages
- cAMP/PKA/CREB
- PDE3
- Inhibitor
- inhibitor
- inhibit