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Cat. No.: HY-184893

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PSH18

PSH18 is a selective monoamine oxidase B (MAO-B) inhibitor with blood-brain barrier permeability, with a human-derived IC₅₀ of 0.95 μM and a K_i of 0.89 μM. PSH18 can be used for the research of Parkinson's disease.

For research use only. We do not sell to patients.

Formula: C₁₈H₁₃FN₄OS
Molecular Weight:352.39

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

PSH18 Chemical Structure

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

IC₅₀ & Target^[1]

hMAO-B

0.95 μM (IC₅₀)

hMAO-B

0.89 μM (Ki)

All Monoamine Oxidase Isoforms :

MAO-A
MAO-B

In Vitro

PSH18 competes with substrates for binding to the active site of MAO-B, and forms stable active site interactions through hydrophobic interactions and π-π stacking^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

Molecular Weight 352.39
Formula C₁₈H₁₃FN₄OS
SMILES

S=C(N/N=C1C(N(CC#C)C2=C\1C=C(F)C=C2)=O)NC3=CC=CC=C3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Parmbil SK, et al. Synthesis, biological evaluation and in silico studies of novel propargyl-tethered isatin hydrazones as monoamine oxidase inhibitors for Parkinson's disease. Scientific reports. 2026 Jun 19. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

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100 mg

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Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References

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PSH18

All Monoamine Oxidase Isoforms