2. Antibody-drug Conjugate/ADC Related
  3. ADC Linker
  4. N3-PEG4-C2-Pfp ester

N3-PEG4-C2-Pfp ester is a nonclaevable 4-unit PEG linker used in the synthesis of antibody-drug conjugates (ADCs). N3-PEG4-C2-Pfp ester is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. Strain-promoted alkyne-azide cycloaddition (SPAAC) can also occur with molecules containing DBCO or BCN groups.

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N3-PEG4-C2-Pfp ester Chemical Structure

N3-PEG4-C2-Pfp ester Chemical Structure

CAS No. : 1353012-00-6

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Based on 1 publication(s) in Google Scholar

N3-PEG4-C2-Pfp ester Related Antibodies

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Description

N3-PEG4-C2-Pfp ester is a nonclaevable 4-unit PEG linker used in the synthesis of antibody-drug conjugates (ADCs). N3-PEG4-C2-Pfp ester is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. Strain-promoted alkyne-azide cycloaddition (SPAAC) can also occur with molecules containing DBCO or BCN groups.

IC50 & Target

Non-cleavable Linker

 

Molecular Weight

457.35

Formula

C17H20F5N3O6
CAS No.
Appearance

Liquid

Color

Colorless to light yellow

SMILES

O=C(OC1=C(F)C(F)=C(F)C(F)=C1F)CCOCCOCCOCCOCCN=[N+]=[N-]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Pure form -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Purity & Documentation

Purity: ≥97.0%

COA (241 KB) HNMR (116 KB)

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N3-PEG4-C2-Pfp ester Related Classifications

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

N3-PEG4-C2-Pfp ester1353012-00-6ADC LinkerAntibody-drug conjugates linkerInhibitorinhibitorinhibit

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N3-PEG4-C2-Pfp ester
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