2. Metabolic Enzyme/Protease Vitamin D Related/Nuclear Receptor
  3. RAR/RXR
  4. NBD-125

NBD-125 (B-12), a berberine analogue, is an RXRα activator, with an IC50 of 31.10 μM in KM12C cell.

For research use only. We do not sell to patients.

NBD-125 Chemical Structure

NBD-125 Chemical Structure

CAS No. : 2367641-24-3

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NBD-125 Related Antibodies

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Description

NBD-125 (B-12), a berberine analogue, is an RXRα activator, with an IC50 of 31.10 μM in KM12C cell[1].

In Vitro

NBD-125 (B-12) exhibits the strongest transcriptional activation ability to RXRα and the greatest inhibitory effect on colon cancer cell growth[1].
NBD-125 (B-12, 0-80, μM) inhibits β-catenin signaling and cell proliferation in colon cancer cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

NBD-125 Related Antibodies

Western Blot Analysis[1]

Cell Line: Km12c, HCT116 and SW620 cell lines.
Concentration: 0-50 μM, 0-60, 0-80 μM.
Incubation Time: 15 h.
Result: Downregulated c-Myc, Cdc42 protein levels.
Molecular Weight

327.80

Formula

C19H18ClNO2
CAS No.
SMILES

COC1=C2C=[N+](CCC3=C4C=CC(OC)=C3)C4=CC2=CC=C1.[Cl-]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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NBD-125 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

NBD-1252367641-24-3NBD125NBD 125RAR/RXRRetinoic acid receptorsRetinoid X receptorsInhibitorinhibitorinhibit

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