1. Metabolic Enzyme/Protease
  2. RAR/RXR
  3. NBD-125

NBD-125 

Cat. No.: HY-133739
Handling Instructions

NBD-125 (B-12), a berberine analogue, is an RXRα activator, with an IC50 of 31.10 μM in KM12C cell.

For research use only. We do not sell to patients.

NBD-125 Chemical Structure

NBD-125 Chemical Structure

CAS No. : 2367641-24-3

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Description

NBD-125 (B-12), a berberine analogue, is an RXRα activator, with an IC50 of 31.10 μM in KM12C cell[1].

IC50 & Target[1].

RXRα

 

In Vitro

NBD-125 (B-12) exhibits the strongest transcriptional activation ability to RXRα and the greatest inhibitory effect on colon cancer cell growth[1].
NBD-125 (B-12, 0-80, μM) inhibits β-catenin signaling and cell proliferation in colon cancer cells[1].

Western Blot Analysis[1]

Cell Line: Km12c, HCT116 and SW620 cell lines.
Concentration: 0-50 μM, 0-60, 0-80 μM.
Incubation Time: 15 h.
Result: Downregulated c-Myc, Cdc42 protein levels.
Molecular Weight

327.80

Formula

C₁₉H₁₈ClNO₂

CAS No.

2367641-24-3

SMILES

COC1=C2C=[N+](CCC3=C4C=CC(OC)=C3)C4=CC2=CC=C1.[Cl-]

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Keywords:

NBD-125NBD125NBD 125RAR/RXRRetinoic acid receptorsRetinoid X receptorsInhibitorinhibitorinhibit

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