2. Apoptosis
  3. Apoptosis
  4. Nemorosone

Nemorosone is the main component of the floral resin of Clusia rosea. Nemorosone has an antiproliferative effect on cancer cells. Nemorosone induces apoptosis in HT-29 and LoVo cells.

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Nemorosone

Nemorosone Chemical Structure

CAS No. : 351416-47-2

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Nemorosone Related Antibodies

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Description

Nemorosone is the main component of the floral resin of Clusia rosea. Nemorosone has an antiproliferative effect on cancer cells. Nemorosone induces apoptosis in HT-29 and LoVo cells[1][2].

IC50 & Target

apoptosis[1]
In Vitro

Nemorosone (0-50 μM; 24-72 h) inhibits the proliferation of HT-29 and LoVo cells with IC50s of 25.7-27.1 μM, 22.8-64.3 μM, respectively[1].
Nemorosone (25.7 μM for HT-29; 22.8 μM for LoVo; 24, 48 hours) increases the percentage of G0/G1 phase cells[1].
Nemorosone (25.7 μM for HT-29; 22.8 μM for LoVo; 24, 48 hours) induces apoptosis in both cell lines[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Nemorosone Related Antibodies

Cell Proliferation Assay[1]

Cell Line: HT-29 and LoVo cells
Concentration: 0-50 μM
Incubation Time: 24-72 h
Result: Inhibited the proliferation of HT-29 and LoVo cells with IC50s of 25.7-27.1 μM, 22.8-64.3 μM, respectively.

Cell Cycle Analysis[1]

Cell Line: HT-29 and LoVo cells
Concentration: 25.7 μM for HT-29; 22.8 μM for LoVo
Incubation Time: 24, 48 hours
Result: Increased the percentage of G0/G1 phase cells.

Apoptosis Analysis[1]

Cell Line: HT-29 and LoVo cells
Concentration: 25.7 μM for HT-29; 22.8 μM for LoVo
Incubation Time: 24, 48 hours
Result: Induced apoptosis in both cell lines.
In Vivo

Nemorosone (50 mg/kg; daily i.p. for 28 days) shows a significant growth-inhibitory effect in pancreatic cancer xenografts[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Athymic NMRI nu/nu nude mices (6 to 8 week old female), which had 100 mm3 MIA-PaCa-2 xenograft tumor[2]
Dosage: 50 mg/kg
Administration: Daily i.p. injections for 28 days
Result: Showed a significant growth-inhibitory effect in pancreatic cancer xenografts[2].
Molecular Weight

502.68

Formula

C33H42O4
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(C1=CC=CC=C1)[C@@]23C([C@@](C(C(C/C=C(C)/C)=C2O)=O)(C[C@H](C/C=C(C)/C)C3(C)C)C/C=C(C)/C)=O
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Purity & Documentation

Purity: 99.0%

SDS (252 KB)

COA (261 KB)

Handling Instructions (2659 KB)
References
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Nemorosone Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Nemorosone351416-47-2ApoptosisCancerHT-29 cellsLoVo cellsMIA-PaCa-2 cellsantiproliferativeInhibitorinhibitorinhibit

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