1. Apoptosis
  2. Apoptosis
  3. Nemorosone

Nemorosone 

Cat. No.: HY-121458
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Nemorosone is the main component of the floral resin of Clusia rosea. Nemorosone has an antiproliferative effect on cancer cells. Nemorosone induces apoptosis in HT-29 and LoVo cells.

For research use only. We do not sell to patients.

Nemorosone Chemical Structure

Nemorosone Chemical Structure

CAS No. : 351416-47-2

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Description

Nemorosone is the main component of the floral resin of Clusia rosea. Nemorosone has an antiproliferative effect on cancer cells. Nemorosone induces apoptosis in HT-29 and LoVo cells[1][2].

IC50 & Target

apoptosis[1]

In Vitro

Nemorosone (0-50 μM; 24-72 h) inhibits the proliferation of HT-29 and LoVo cells with IC50s of 25.7-27.1 μM, 22.8-64.3 μM, respectively[1].
Nemorosone (25.7 μM for HT-29; 22.8 μM for LoVo; 24, 48 hours) increases the percentage of G0/G1 phase cells[1].
Nemorosone (25.7 μM for HT-29; 22.8 μM for LoVo; 24, 48 hours) induces apoptosis in both cell lines[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay[1]

Cell Line: HT-29 and LoVo cells
Concentration: 0-50 μM
Incubation Time: 24-72 h
Result: Inhibited the proliferation of HT-29 and LoVo cells with IC50s of 25.7-27.1 μM, 22.8-64.3 μM, respectively.

Cell Cycle Analysis[1]

Cell Line: HT-29 and LoVo cells
Concentration: 25.7 μM for HT-29; 22.8 μM for LoVo
Incubation Time: 24, 48 hours
Result: Increased the percentage of G0/G1 phase cells.

Apoptosis Analysis[1]

Cell Line: HT-29 and LoVo cells
Concentration: 25.7 μM for HT-29; 22.8 μM for LoVo
Incubation Time: 24, 48 hours
Result: Induced apoptosis in both cell lines.
In Vivo

Nemorosone (50 mg/kg; daily i.p. for 28 days) shows a significant growth-inhibitory effect in pancreatic cancer xenografts[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Athymic NMRI nu/nu nude mices (6 to 8 week old female), which had 100 mm3 MIA-PaCa-2 xenograft tumor[2]
Dosage: 50 mg/kg
Administration: Daily i.p. injections for 28 days
Result: Showed a significant growth-inhibitory effect in pancreatic cancer xenografts[2].
Molecular Weight

502.68

Formula

C₃₃H₄₂O₄

CAS No.
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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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