Azacyclonol
Based on 1 publication(s) in Google Scholar
Azacyclonol (γ-pipradol), a metabolite of Terfenadine, is a central depressant agent. Azacyclonol is a ganglion-blocking agent. Azacyclonol can be used to diminish psychoses-induced hallucinations.
For research use only. We do not sell to patients.
- Purity: 99.93%
- CAS No.: 115-46-8
- Formula: C18H21NO
- Molecular Weight:267.37
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Publications Citing Use of MedChemExpress (MCE) Azacyclonol
MoreAll Histamine Receptor Isoforms
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Biological Activity
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Cell Line
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Type | Value | Description | References |
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| L929 | IC50 |
>100 μM
Compound: 6
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Inhibition of human ERG in L929 cells at 10 uM by whole cell patch-clamp assay
Inhibition of human ERG in L929 cells at 10 uM by whole cell patch-clamp assay
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[PMID: 19660947] |
| L929 | IC50 |
>100 μM
Compound: 6
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Inhibition of human ERG in L929 cells by whole cell patch-clamp assay
Inhibition of human ERG in L929 cells by whole cell patch-clamp assay
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[PMID: 19660947] |
Azacyclonol is formed from Terfenadine in rat liver[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Azacyclonol antagonizes increased coordination activity in mice induced by pipradrol, amphetamine, morphine and cocaine and prolongs Hexobarbital hypnosis[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 115-46-8
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Appearance Solid
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Molecular Weight 267.37
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Formula C18H21NO
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Color White to off-white
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SMILES
OC(C1=CC=CC=C1)(C2CCNCC2)C3=CC=CC=C3
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Synonyms
γ-pipradol
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year
Publications (1)
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Journal Impact Factor
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Most Recent
Solvent & Solubility
DMSO : 100 mg/mL (374.01 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (9.35 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (9.35 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation
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Data Sheet (277 KB)
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SDS (393 KB)
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Handling Instructions (2659 KB)
References
[1]. Brown DA, et, al. The effects of some centrally acting drugs on ganglionic transmission in the cat. [Content Brief]
[2]. Jurima-Romet M, et, al. Induction of CYP3A and associated terfenadine N-dealkylation in rat hepatocytes cocultured with 3T3 cells. Cell Biol Toxicol. 1995 Dec;11(6):313-27. [Content Brief]
[3]. BRAUN DL, et, al. The pharmacologic activity of alpha-(4-piperidyl)-benzhydrol hydrochloride (azacyclonol hydrochloride); an ataractive agent. J Pharmacol Exp Ther. 1956 Oct;118(2):153-61. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.7401 mL | 18.7005 mL | 37.4011 mL | 93.5027 mL |
| 5 mM | 0.7480 mL | 3.7401 mL | 7.4802 mL | 18.7005 mL | |
| 10 mM | 0.3740 mL | 1.8701 mL | 3.7401 mL | 9.3503 mL | |
| 15 mM | 0.2493 mL | 1.2467 mL | 2.4934 mL | 6.2335 mL | |
| 20 mM | 0.1870 mL | 0.9350 mL | 1.8701 mL | 4.6751 mL | |
| 25 mM | 0.1496 mL | 0.7480 mL | 1.4960 mL | 3.7401 mL | |
| 30 mM | 0.1247 mL | 0.6234 mL | 1.2467 mL | 3.1168 mL | |
| 40 mM | 0.0935 mL | 0.4675 mL | 0.9350 mL | 2.3376 mL | |
| 50 mM | 0.0748 mL | 0.3740 mL | 0.7480 mL | 1.8701 mL | |
| 60 mM | 0.0623 mL | 0.3117 mL | 0.6234 mL | 1.5584 mL | |
| 80 mM | 0.0468 mL | 0.2338 mL | 0.4675 mL | 1.1688 mL | |
| 100 mM | 0.0374 mL | 0.1870 mL | 0.3740 mL | 0.9350 mL |
Azacyclonol Related Classifications
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