BMS-952048
BMS-952048 is a positive allosteric modulator of mGluR5 with an EC50 of 10 nM.
For research use only. We do not sell to patients.
- CAS No.: 1375751-32-8
- Formula: C21H13F2N3O2
- Molecular Weight:377.34
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
- Purity & Documentation
- References
-
Help & FAQs
Biological Activity
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| HEK293 | EC50 |
>3000 nM
Compound: 22; BMS-952048
|
Agonist activity at human mGluR5A transfected in HEK293 cells assessed as induction of calcium release by FLIPR assay
Agonist activity at human mGluR5A transfected in HEK293 cells assessed as induction of calcium release by FLIPR assay
|
[PMID: 27496211] |
| HEK293 | EC50 |
10 nM
Compound: 22; BMS-952048
|
Positive allosteric modulation of human mGluR5A transfected in HEK293 cells assessed as potentiation of L-glutamate-induced calcium release incubated for 10 mins by FLIPR assay
Positive allosteric modulation of human mGluR5A transfected in HEK293 cells assessed as potentiation of L-glutamate-induced calcium release incubated for 10 mins by FLIPR assay
|
[PMID: 27496211] |
Chemical Information
-
CAS No. 1375751-32-8
-
Molecular Weight 377.34
-
Formula C21H13F2N3O2
-
SMILES
O=C1O[C@H](C2=CC=C(F)C=C2)[C@@H](C3=CC(C#CC4=NC=CC=C4F)=CN=C3)N1
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
BMS-952048 Related Classifications
HY-123874 Related Classifications
Powered by Bioz