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Cat. No.: HY-116562

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DK-139

DK-139 is a polyphenol compound bearing a cinnamaldehyde scaffol. DK-139 inhibits clonogenic growth of Cisplatin (HY-17394)-resistant human ovarian cancer. DK-139 can be used for the research of Cisplatin-resistant ovarian cancer.

For research use only. We do not sell to patients.

CAS No.: 1426059-23-5
Formula: C₁₈H₁₈O₅
Molecular Weight:314.33

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

DK-139 Chemical Structure

CAS No.: 1426059-23-5

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
- In Vitro
Chemical Information
Purity & Documentation
References
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Bioz

Biological Activity

Description

Cellular Effect

Cell Line	Type	Value	Description	References
A2780cisR	GI₅₀	11.3 μM Compound: 17	Growth inhibition of cisplatin-resistant human A2780cis cells after 7 days by crystal violet staining based clonogenic assay Growth inhibition of cisplatin-resistant human A2780cis cells after 7 days by crystal violet staining based clonogenic assay	[PMID: 24565968]

In Vitro

DK-139 (Compound 17) (5-20 μM; 7 days) inhibits clonogenic growth of Cisplatin (HY-17394)-resistant human ovarian cancer A2780/Cis cells with a GI₅₀ of 11.30 μM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay^[1]

Cell Line:

Cisplatin-resistant human ovarian cancer A2780/Cis cells
Concentration:

5, 10, 20 μM
Incubation Time:

7 days
Result:

Exhibited a half-maximal cell growth inhibitory concentration (GI₅₀) of 11.30 μM.

Chemical Information

CAS No. 1426059-23-5
Molecular Weight 314.33
Formula C₁₈H₁₈O₅
SMILES

O=C(C1=CC(OC)=CC=C1O)/C=C/C2=CC(OC)=CC(OC)=C2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Shin SY, et al. Polyphenols bearing cinnamaldehyde scaffold showing cell growth inhibitory effects on the cisplatin-resistant A2780/Cis ovarian cancer cells. Bioorg Med Chem. 2014;22(6):1809-1820. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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