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Cat. No.: HY-12855

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Lys01

4 Cited Publications

Customer Review

Based on 4 publication(s) in Google Scholar

Lys01, a dimeric form of Chloroquine (HY-17589A), is an autophagy inhibitor. Lys01 inhibits cell viability of 1205Lu, c8161, LN229, HT-29 cells with IC₅₀s of 3.6, 3.8, 7.9, 6.0 μM. Lys01 can be used for anticancer research.

For research use only. We do not sell to patients.

CAS No.: 1391426-22-4
Formula: C₂₃H₂₃Cl₂N₅
Molecular Weight:440.37

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (266 KB)

Lys01 Chemical Structure

CAS No.: 1391426-22-4

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
Chemical Information
Publications (4)
Purity & Documentation
References
Calculators
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Bioz

Biological Activity

Description

Cellular Effect

Cell Line	Type	Value	Description	References
A375P	IC₅₀	2.87 μM Compound: 1; DC221	Cytotoxicity against human A375P cells incubated for 72 hrs by MTT assay Cytotoxicity against human A375P cells incubated for 72 hrs by MTT assay	[PMID: 34298133]

Chemical Information

CAS No. 1391426-22-4
Molecular Weight 440.37
Formula C₂₃H₂₃Cl₂N₅
SMILES

CN(CCNC1=CC=NC2=C1C=CC(Cl)=C2)CCNC3=CC=NC4=CC(Cl)=CC=C43
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Publications (4)

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Nat Microbiol

Modulation of virus-induced neuroinflammation by the autophagy receptor SHISA9 in mice. [Abstract]

2023 May;8(5):958-972. PMID: 37081201

Lys01 purchased from MedChemExpress. Usage Cited in: Nat Microbiol. 2023 May;8(5):958-972. [Abstract]

Lys05 (16 mg/kg; i.c) increased the production of inflammatory cytokines in WT and Shisa9^-/- mice.

Lys01 purchased from MedChemExpress. Usage Cited in: Nat Microbiol. 2023 May;8(5):958-972. [Abstract]

Lys05 (16 mg/kg; i.c.) increased the mortality of both WT and Shisa9^-/- mice.

Lys01 purchased from MedChemExpress. Usage Cited in: Nat Microbiol. 2023 May;8(5):958-972. [Abstract]

Lys05 (16 mg/kg; i.c.) increased the disease score of both WT and Shisa9^-/- mice.

Lys01 purchased from MedChemExpress. Usage Cited in: Nat Microbiol. 2023 May;8(5):958-972. [Abstract]

Lys05 (16 mg/kg; i.c.) abolished Shisa9's function in regulating the expression of IKKi-dependent genes in WT and Shisa9^-/- mice.
J Transl Med

NL101 synergizes with the BCL-2 inhibitor venetoclax through PI3K-dependent suppression of c-Myc in acute myeloid leukaemia. [Abstract]

2024 Sep 27;22(1):867. PMID: 39334157
FASEB J

Downregulation of EZH2 Promotes Renal Epithelial Cellular Senescence and Kidney Aging. [Abstract]

2025 May 15;39(9):e70605. PMID: 40326780

Lys01 purchased from MedChemExpress. Usage Cited in: FASEB J. 2025 May 15;39(9):e70605. [Abstract]

Lys05 (2-5 μM; 48 h) decreased the levels of LC3 and increased the levels of p62 in senescent RCTE cells induced by IR.
Environ Toxicol

RNF168 suppresses the cancer stem cell-like traits of nonsmall cell lung cancer cells by mediating RhoC ubiquitination. [Abstract]

2022 Mar;37(3):603-611. PMID: 34873829

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (266 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. McAfee Q, et al. Autophagy inhibitor Lys05 has single-agent antitumor activity and reproduces the phenotype of a genetic autophagy deficiency. Proc Natl Acad Sci U S A. 2012 May 22;109(21):8253-8. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biological Activity
- Description
Chemical Information
Publications (4)
Purity & Documentation
References

1/16
1/16

Lys01 purchased from MedChemExpress. Usage Cited in: FASEB J. 2025 May 15;39(9):e70605. [Abstract]

Customer Validation
Lys05 (2-5 μM; 48 h) decreased the levels of LC3 and increased the levels of p62 in senescent RCTE cells induced by IR.
1/16

Lys01 purchased from MedChemExpress. Usage Cited in: Nat Microbiol. 2023 May;8(5):958-972. [Abstract]

Customer Validation
Lys05 (16 mg/kg; i.c) increased the production of inflammatory cytokines in WT and Shisa9^-/- mice.
1/16

Lys01 purchased from MedChemExpress. Usage Cited in: Nat Microbiol. 2023 May;8(5):958-972. [Abstract]

Customer Validation
Lys05 (16 mg/kg; i.c.) increased the mortality of both WT and Shisa9^-/- mice.
1/16

Lys01 purchased from MedChemExpress. Usage Cited in: Nat Microbiol. 2023 May;8(5):958-972. [Abstract]

Customer Validation
Lys05 (16 mg/kg; i.c.) increased the disease score of both WT and Shisa9^-/- mice.
1/16

Lys01 purchased from MedChemExpress. Usage Cited in: Nat Microbiol. 2023 May;8(5):958-972. [Abstract]

Customer Validation
Lys05 (16 mg/kg; i.c.) abolished Shisa9's function in regulating the expression of IKKi-dependent genes in WT and Shisa9^-/- mice.

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Lys01

Publications Citing Use of MedChemExpress (MCE) Lys01