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Remigromig

(Synonyms: EYE-103; MK-3000)
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Based on 1 Customer Validation

Remigromig (EYE-103; MK-3000) is a humanized dual-target monoclonal antibody that targets LRP5 and FZD4. Remigromig activates the Wnt/β-catenin signaling pathway by mimicking the natural ligand Norrin, induces tight junction formation and restores blood-retinal barrier function. Administered via intravitreal injection, Remigromig reduces retinal vascular leakage, and demonstrates improvements in best-corrected visual acuity and reductions in retinal thickness in studies of diabetic macular edema. Remigromig can be used for research related to macular degeneration.

For research use only. We do not sell to patients.

  • Purity: 95.25%
  • CAS No.: 3059389-31-7
  • Molecular Weight:199.68 kDa
  • Storage:

    Please store the product under the recommended conditions in the Certificate of Analysis.

  • Experimental Validation Results for Remigromig
  • Experimental Validation Results for Remigromig
  • Experimental Validation Results for Remigromig
  • Remigromig Chemical Structure
    Remigromig Chemical Structure
CAS No.: 3059389-31-7
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To place orders, for customer services and technical support, please contact: MedChemExpress USA

Tel: 609-228-6898 E-mail: [email protected] [email protected]

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Remigromig Product Recommendations:

To place orders, for customer services and technical support, please contact:

609-228-6898
[email protected] [email protected]
Find Your Local Distributor Your local distributor: Hycultec GmbHHycultec
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Top Publications Citing

Use of MCE Products

All Wnt Isoforms

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  • 1/16

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  • 1/16

    Immobilized Frizzled-4/CD344 Protein, Human (HEK293, HY-P74140) can bind Remigromig. The ED50 for this effect is 17.22 ng/mL.

  • 1/16

    Immobilized LRP-5 Protein, Human (HEK293, HY-P77989) can bind Remigromig. The ED50 for this effect is 891.6 ng/mL.

  • Remigromig Chemical Structure
    1/16
  • Remigromig
  • Immobilized Frizzled-4/CD344 Protein, Human (HEK293, HY-P74140) can bind Remigromig. The ED50 for this effect is 17.22 ng/mL.
  • Immobilized LRP-5 Protein, Human (HEK293, HY-P77989) can bind Remigromig. The ED50 for this effect is 891.6 ng/mL.
  • Product Image