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Cat. No.: HY-182916

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NNRT-IN-16

NNRT-IN-16, Rilpivirin (HY-10574) analogue, is a non-nucleoside reverse transcriptase inhibitor (NNRTI). NNRT-IN-16 inhibits recombinant WT HIV-1 RT with an IC₅₀ of 0.07 μM. NNRT-IN-16 exerts antiviral activity against wild-type and drug-resistant HIV-1 mutants, shows attenuated CYP isoenzyme and hERG inhibition, reduced cytotoxicity, and improved metabolic stability in human liver microsomes. NNRT-IN-16 can be used for the research of HIV-1 infection.

For research use only. We do not sell to patients.

Formula: C₂₂H₁₈FN₇
Molecular Weight:399.42

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Please store the product under the recommended conditions in the Certificate of Analysis.

NNRT-IN-16 Chemical Structure

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
- Parmacokinetics
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

IC₅₀ & Target^[1]

HIV-1 (WT)

0.07 μM (IC₅₀)

All HIV Isoforms :

In Vitro

NNRT-IN-16 (Compound A24) inhibits recombinant WT HIV-1 RT with an IC₅₀ of 0.07 μM^[1].
NNRT-IN-16 inhibits WT HIV-1 replication in MT-4 cells with an EC₅₀ of 2.21 nM and has a CC₅₀ of 82.3 μM in MT-4 cells^[1].
NNRT-IN-16 inhibits replication of clinically relevant drug-resistant HIV-1 mutants in MT-4 cells with EC₅₀ values ranging from 2.07 to 28.8 nM and RF values between 0.93 and 13.0^[1].
NNRT-IN-16 (A24) inhibits hERG potassium channels in CHO-hERG cells with an IC₅₀ of 2.633 μM, showing low cardiotoxicity risk^[1].
NNRT-IN-16 inhibits human CYP isoforms with IC₅₀ values ranging from 1.88 μM to >25.0 μM, indicating reduced drug-drug interaction potential^[1].
NNRT-IN-16 exhibits species-dependent metabolic stability, with enhanced stability in human liver microsomes (T_1/2 = 39.1 min)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Parmacokinetics

Species	Dose	Route	T_1/2	T_max	C_max	AUC_0-t	AUC_0-∞	CL	MRT_0-t	MRT_0-∞	F
Rat^[1]	1 mg/kg	i.v.	0.69 h	0.08 h	264 ng/mL	121 ng·h/mL	123 ng·h/mL	8210 mL/h/kg	0.56 h	0.64 h	/
Rat^[1]	10 mg/kg	p.o.	1.63 h	0.63 h	45.7 ng/mL	118 ng/mL	123 ng·h/mL	/	2.00 h	2.38 h	10.01 %

Chemical Information

Molecular Weight 399.42
Formula C₂₂H₁₈FN₇
SMILES

NC1=C(N=C(N=C1)NC2=C(C=C(C=C2)C#N)F)NC3=C(C=C(C=C3C)/C=C/C#N)C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Zhang K, et al. Rational Design of Broad-Spectrum Non-Nucleoside Reverse Transcriptase Inhibitors via Pharmacophore-Oriented Generative Artificial Intelligence. J Med Chem. 2026;69(7):8503-8520. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References

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NNRT-IN-16

All HIV Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

NNRT-IN-16 Related Classifications

HY-182916 Related Classifications