NP7r
NP7r is an antioxidant and neuroprotective agent. NP7r regulates oxidative stress, upregulates downstream antioxidant genes, reduces mitochondrial ROS, initiates Autophagy and clears α-synuclein aggregates. NP7r alleviates dopaminergic neuron degeneration, restores fat content, reduces lipid peroxidation, and improves motor impairment and abnormal food perception. NP7r is applicable to the research of Parkinson's disease.
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- CAS No.: 2641092-28-4
- Formule: C26H20O3
- Masse moléculaire:380.44
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Activité biologique
NP7r (10 μM) protects *Caenorhabditis elegans* against 6-OHDA (HY-B1081)-induced dopaminergic neuron degeneration, restoring the total fluorescence intensity of dopaminergic neurons to 96.28% of that in the control group[1].
NP7r (10 μM) alleviates 6-OHDA-induced growth and behavioral defects in wild-type *Caenorhabditis elegans*, restoring its movement and feeding-related behaviors to levels close to those of the control group[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:NL5901 pkIs2386 [unc-54p::alpha-synuclein:YFP + unc-119(+)][1]
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Dosage:10 μM; 20 μM; 40 μM; 80 μM
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Administration:nematode growth medium; 48 hours
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Result:Significantly reduced mitochondrial ROS levels in NL5901 worms (effect dependent on skn-1 gene).
Decreased α-synuclein-YFP fluorescence intensity by ~30% relative to untreated controls.
Reduced MDA levels and partially restored lipid droplet area in NL5901 worms.
Upregulated mRNA levels of skn-1, gst-4, gcs-1, cct-2, cct-3, cct-4, cct-6, cct-7, cct-8, lgg-1, unc-51, epg-5, epg-8, vps-35, and atg-7.
Downregulated daf-16 and sod-3 mRNA levels.
Increased GSH levels and restored GST-4::GFP fluorescence intensity in 6-OHDA-treated CL2166 worms.
Confirmed α-synuclein clearance effect dependent on cct-6, lgg-1, and unc-51 genes.
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Animal Model:BZ555 egls1[Pdat-1::gfp][1]
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Dosage:10 μM
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Administration:nematode growth medium; post-6-OHDA exposure
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Result:Restored total dopaminergic neuron fluorescence intensity to 96.28% of untreated BZ555 levels, representing a 36.23% increase relative to 6-OHDA-only treated worms.
Restored fluorescence intensity of cephalic (CEP), anterior deirid (ADE), and posterior deirid (PDE) dopaminergic neurons.
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Animal Model:N2[1]
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Dosage:10 μM
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Administration:nematode growth medium; post-6-OHDA exposure
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Result:Restored 6-OHDA-reduced body length, tail thrashing frequency, slowing rate, travel distance, velocity, and body bend frequency in N2 worms to levels statistically comparable to untreated controls.
Chemical Information
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CAS No. 2641092-28-4
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Masse moléculaire 380.44
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Formule C26H20O3
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SMILES
O=C1CCC2=C1C(C3=CC=CC=C3)=CC(C4=CC=C(C=C4)O)(O2)C5=CC=CC=C5
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
NP7r Related Classifications
HY-184558 Related Classifications
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