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NQTrp 

Cat. No.: HY-19738
Handling Instructions

NQTrp, an aromatic naphthoquinone-tryptophan hybrid molecule, an inhibitor of the aggregation of the tau protein with generic anti-amyloidogenic effects. NQTrp inhibits the in vitro aggregation of hexapeptide (41GCWMLY46 within the N-terminus of γD-crystallin) as well as full-length γD-crystallin.

For research use only. We do not sell to patients.

NQTrp Chemical Structure

NQTrp Chemical Structure

CAS No. : 185351-19-3

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Description

NQTrp, an aromatic naphthoquinone-tryptophan hybrid molecule, an inhibitor of the aggregation of the tau protein with generic anti-amyloidogenic effects. NQTrp inhibits the in vitro aggregation of hexapeptide (41GCWMLY46 within the N-terminus of γD-crystallin) as well as full-length γD-crystallin[1].

In Vitro

In TEM analysis, GDC6 peptide fibrils (50 μM) in the presence of NQTrp 5:1, 1:1, 1:5 ratio (GDC6: NQTrp). NQTrp effectively inhibits the fibrillation of the GDC6 peptide (50 μM) in a dose-dependent manner and prevents the formation of elongated amyloid fibrils[1].
NQTrp has no toxic effect toward retinal cell culture and reduces the cytotoxicity induced by aggregates of the hexapeptide(IC50=70 μM) in ARPE-19 cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

360.36

Formula

C₂₁H₁₆N₂O₄

CAS No.
SMILES

O=C(O)[[email protected]](CC1=CNC2=CC=CC=C12)NC(C3=O)=CC(C4=C3C=CC=C4)=O

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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

NQTrpOthersTau ProteinaggregationγD-crystallinhexapeptideamyloidogenicfibrilsInhibitorinhibitorinhibit

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