Nrf2 activator-20
Nrf2 activator-20 is a potent Nrf2 activator with anti-inflammatory and antioxidant activities. Nrf2 activator-20 activates the anti-inflammatory pathway by interfering with the Keap1-Nrf2 interaction and is beneficial in vivo. Nrf2 activator-20 can be used for the study of acute respiratory distress syndrome (ARDS) and ischemia-reperfusion injury.
For research use only. We do not sell to patients.
- CAS No.: 89883-16-9
- Formula: C7H5Br3O2
- Molecular Weight:360.83
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Nrf2 activator-20 (Compound AP9) (1 μM, 2 h) strongly induces the Nrf2 pathway in both LPS (HY-D1056) stimulated and non-stimulated RAW cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:RAW264.7 cells
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Concentration:1 μM
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Incubation Time:2 h
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Result:Induced nuclear translocation of Nrf2 significantly while inducing HO-1 expression at nanomolar concentrations.
Nrf2 activator-20 (0.78 mg/kg, i.p., single dose) alleviate the lung injury in the mice model induced by E. coli[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Warm liver ischemia/reperfusion injury model established in C57BL/6J mice (9-14 weeks old, 27 g)[1]
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Dosage:0.78 mg/kg
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Administration:Intraperitoneal injection (i.p.), single dose prior to surgery
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Result:Significantly reduced plasma ALT and AST as well as hepatocellular injury.
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Animal Model:Lung injury model induced by E. coli treatment established in 11–12 week old male C57BL/6 mice[1]
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Dosage:0.78 mg/kg
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Administration:Intraperitoneal injection (i.p.), single dose
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Result:Improved oxygenation during E. coli-induced lung injury.
Chemical Information
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CAS No. 89883-16-9
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Molecular Weight 360.83
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Formula C7H5Br3O2
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SMILES
O=C1C(Br)=C(Br)C(O)(C)C=C1Br
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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