NS3763 

NS3763 is a selective and noncompetitive GLU_K5 receptor antagonist with an IC₅₀ of 1.6 µM. NS3763 does not show significant antagonistic properties on GLU_K6, AMPA or NMDA receptors^[1].

IC50: 1.6 µM (GLU_K5 receptor)^[1]

In human embryonic kidney HEK293 cells expressing homomeric GLU_K5 or GLU_K6 receptors, NS3763 displays selectivity for inhibition of domoate-induced increase in intracellular calcium mediated through the GLUK5 subtype (IC₅₀ = 1.6 µM) of kainate receptors compared with the GLUK6 subtype (IC₅₀ > 30 µM)^[1].
NS3763 selectively inhibits l-glutamate- and domoate-evoked currents through GLU_K5 receptors in HEK293 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

404.37

C₂₂H₁₆N₂O₆

70553-45-6

O=C(C1=C(NC(C2=CC=CC=C2)=O)C=C(NC(C3=CC=CC=C3)=O)C(C(O)=O)=C1)O

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Jeppe K Christensen, et al. In vitro characterization of 5-carboxyl-2,4-di-benzamidobenzoic acid (NS3763), a noncompetitive antagonist of GLUK5 receptors. J Pharmacol Exp Ther. 2004 Jun;309(3):1003-10.  [Content Brief]