MRL20
MRL20 is a PPARγ constitutive and allosteric agonist. MRL20 enhances the interaction between PPARγ and the co-activating peptide of TRAP220, with its EC50 being 10 nM. Even after being covalently blocked in the constitutive pocket by GW9662 (HY-16578) or T0070907 (HY-13202), MRL20 can still strengthen the interaction between PPARγ and TRAP220, with EC50 values of 176 and 440 nM respectively. MRL20 fails to completely inhibit its cell activation effect. MRL20 can be used to study the allosteric regulatory mechanism of PPARγ.
For research use only. We do not sell to patients.
- CAS No.: 393794-32-6
- Formula: C28H24F3NO6
- Molecular Weight:527.49
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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PPAR-γ 10 nM (EC50) |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| COS-1 | EC50 |
0.002 μM
Compound: 20
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In vitro maximal activation of human Peroxisome proliferator activated receptor gamma in COS-1 cell transactivation assay
In vitro maximal activation of human Peroxisome proliferator activated receptor gamma in COS-1 cell transactivation assay
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[PMID: 15603954] |
Chemical Information
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CAS No. 393794-32-6
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Molecular Weight 527.49
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Formula C28H24F3NO6
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SMILES
O=C(C1=CC=C(C=C1)OC)N2C3=CC=C(OC(F)(F)F)C=C3C(CC4=C(C=CC=C4)O[C@@H](C)C(O)=O)=C2C
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
MRL20 Related Classifications
HY-122222 Related Classifications
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