Complement Component 1
Complement component 1 (C1) is the first component of the classical complement pathway, assembled as a calcium-dependent complex of one C1q molecule and two copies each of the serine protease proenzymes C1r and C1s. C1q, a flower-bunch-shaped protein with six collagen-like stalks and globular heads, recognizes immune complexes, apoptotic debris, and certain pathogens, triggering autoactivation of C1r, which then cleaves C1s. Activated C1s subsequently cleaves C4 and C2 to form the C3 convertase C4b2a. Deficiency of C1q is strongly associated with systemic lupus erythematosus and severe recurrent infection, and recombinant or purified C1q subcomponents are used in complement pathway assays and autoantibody detection.
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Complement Component 1 Recombinant Proteins (5)
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Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- Formula: Human
- Molecular Weight: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
