Olmesartan-d6
Based on 1 Customer Validation
Olmesartan-d6 (RNH-6270-d6) is the deuterium labeled Olmesartan. Olmesartan (RNH-6270) is an angiotensin II receptor (AT1R) antagonist used to treat high blood pressure.
Para uso exclusivo en investigación. No vendemos a pacientes.
- Pureza : 99.26%
- No. CAS: 1185144-74-4
- Fòrmula: C24H20D6N6O3
- Peso molecular:452.54
-
Almacenamiento:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Actividad biológica
-
Chemical Information
-
Solvente y solubilidad
- Pureza y Documentación
- Referencias
-
Help & FAQs
-
HY-14914S
Azilsartan-d5Angiotensin II Receptor Antagonist -
HY-B0202S
Irbesartan-d4Stable Isotope -
HY-B0279S
Ramipril-d5Stable Isotope -
HY-N0091S5
Hypoxanthine-d4Stable Isotope -
HY-18204
ValsartanAngiotensin II Receptor Antagonist -
HY-17005S
Olmesartan medoxomil-d6Stable Isotope -
HY-B0351S
Taurine-d4Stable Isotope -
HY-N0326S7
L-Methionine-d3Stable Isotope -
HY-A0166S
Cilastatin-15N,d3Stable Isotope -
HY-17512A
Losartan potassiumAT1 Antagonist -
HY-18204S
Valsartan-d9 -
HY-N0469S
L-Lysine-d3 hydrochlorideStable Isotope
Ver todos los productos específicos de isoformas Angiotensin Receptor
More
Actividad biológica
Descripciòn
IC50 & Target
|
AT1 Receptor |
In Vitro
Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Aplicación
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
-
No. CAS 1185144-74-4
-
Unlabeled CAS 144689-24-7
-
Appearance Solid
-
Peso molecular 452.54
-
Fòrmula C24H20D6N6O3
-
Color White to off-white
-
SMILES
OC(C(N1CC2=CC=C(C3=C(C4=NN=NN4)C=CC=C3)C=C2)=C(N=C1CCC)C(C([2H])([2H])[2H])(O)C([2H])([2H])[2H])=O
-
Synonyms
RNH-6270-d6
-
Envío
Room temperature in continental US; may vary elsewhere.
-
Almacenamiento
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvente y solubilidad
In Vitro:
DMSO : 20.83 mg/mL (46.03 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureza y Documentación
-
Ficha de datos (279 KB)
-
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
-
Instrucciones de manejo (2659 KB)
Referencias
[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]
[2]. Yanagihara H, et al. Effects of telmisartan and olmesartan on insulin sensitivity and renal function in spontaneously hypertensive rats fed a high fat diet. J Pharmacol Sci. 2016 Jul;131(3):190-7. [Content Brief]
[3]. Tanno T, et al. Olmesartan Inhibits Cardiac Hypertrophy in Mice Overexpressing Renin Independently of Blood Pressure: Its Beneficial Effects on ACE2/Ang(1-7)/Mas Axis and NADPH Oxidase Expression. J Cardiovasc Pharmacol. 2016 Jun;67(6):503-9. [Content Brief]
[4]. Bakhtiari E, et al. Synergistic, cytotoxic and apoptotic activities of olmesartan with NF-κB inhibitor against HeLa human cell line. Toxicol Mech Methods. 2015;25(8):614-21. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.2097 mL | 11.0487 mL | 22.0975 mL | 55.2437 mL |
| 5 mM | 0.4419 mL | 2.2097 mL | 4.4195 mL | 11.0487 mL | |
| 10 mM | 0.2210 mL | 1.1049 mL | 2.2097 mL | 5.5244 mL | |
| 15 mM | 0.1473 mL | 0.7366 mL | 1.4732 mL | 3.6829 mL | |
| 20 mM | 0.1105 mL | 0.5524 mL | 1.1049 mL | 2.7622 mL | |
| 25 mM | 0.0884 mL | 0.4419 mL | 0.8839 mL | 2.2097 mL | |
| 30 mM | 0.0737 mL | 0.3683 mL | 0.7366 mL | 1.8415 mL | |
| 40 mM | 0.0552 mL | 0.2762 mL | 0.5524 mL | 1.3811 mL |
Olmesartan-d6 Related Classifications
HY-17004S1 Related Classifications
Powered by Bioz