Ozarelix (Synonyms: D-63153)

Cat. No.: HY-16375: FAQs
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Ozarelix (D-63153) is a GnRH antagonist. Ozarelix induces cell apoptosis and arrests cell in G2/M phase. Ozarelix can be used in the research of prostate cancer.

For research use only. We do not sell to patients.

Ozarelix Chemical Structure

CAS No. : 295350-45-7

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Description

Ozarelix (D-63153) is a GnRH antagonist. Ozarelix induces cell apoptosis and arrests cell in G2/M phase. Ozarelix can be used in the research of prostate cancer^[1].

In Vitro

Ozarelix (0-20 ng/mL, 72 h) inhibits PC3 and DU145 cell proliferation^[1].
Ozarelix (0-20 ng/mL, 72 h) induces apoptosis in PC3 and DU145 cells^[1].
Ozarelix (20 ng/mL, 72 h) triggers caspase 8-dependent caspase 3 activation^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay^[1]

Cell Line:	Serum-starved PC3 and DU145 cells
Concentration:	0, 5, 10, 20 ng/mL
Incubation Time:	0, 24, 48, 72, 96 h
Result:	Inhibited cell proliferation in a dose and time-dependent manner.

Western Blot Analysis^[1]

Cell Line:	PC3 and DU145 cells
Concentration:	0, 5, 10, 20 ng/mL
Incubation Time:	72 h
Result:	Increased the levels of p21 and p27 both in PC3 and DU145 cells. Decreased levels of anti-apoptotic proteins such as Bcl2 and Bcl-Xl. Upregulated Erk and p38MAPK activity.

Clinical Trial

Molecular Weight

1459.09

Formula

C₇₂H₉₆ClN₁₇O₁₄

CAS No.

295350-45-7

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Festuccia C, et al. Ozarelix, a fourth generation GnRH antagonist, induces apoptosis in hormone refractory androgen receptor negative prostate cancer cells modulating expression and activity of death receptors. Prostate. 2010 Sep 1;70(12):1340-9. [Content Brief]

Ozarelix Related Classifications

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Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Ozarelix295350-45-7D-63153D63153D 63153GnRH ReceptorApoptosisGonadotropin releasing hormone receptorGNRHRCancerDU145PC3prostate cancerantiproliferationInhibitorinhibitorinhibit

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