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Cat. No.: HY-16375

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Ozarelix

(Synonyms: D-63153)

Ozarelix (D-63153) is a GnRH antagonist. Ozarelix induces cell apoptosis and arrests cell in G2/M phase. Ozarelix can be used in the research of prostate cancer.

For research use only. We do not sell to patients.

CAS No.: 295350-45-7
Formula: C₇₂H₉₆ClN₁₇O₁₄
Molecular Weight:1459.09

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Ozarelix Chemical Structure

CAS No.: 295350-45-7

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
- Clinical Trial
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

Ozarelix (D-63153) is a GnRH antagonist. Ozarelix induces cell apoptosis and arrests cell in G2/M phase. Ozarelix can be used in the research of prostate cancer^[1].

In Vitro

Ozarelix (0-20 ng/mL, 72 h) inhibits PC3 and DU145 cell proliferation^[1].
Ozarelix (0-20 ng/mL, 72 h) induces apoptosis in PC3 and DU145 cells^[1].
Ozarelix (20 ng/mL, 72 h) triggers caspase 8-dependent caspase 3 activation^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay^[1]

Cell Line:

Serum-starved PC3 and DU145 cells
Concentration:

0, 5, 10, 20 ng/mL
Incubation Time:

0, 24, 48, 72, 96 h
Result:

Inhibited cell proliferation in a dose and time-dependent manner.

Western Blot Analysis^[1]

Cell Line:

PC3 and DU145 cells
Concentration:

0, 5, 10, 20 ng/mL
Incubation Time:

72 h
Result:

Increased the levels of p21 and p27 both in PC3 and DU145 cells.
Decreased levels of anti-apoptotic proteins such as Bcl2 and Bcl-Xl.
Upregulated Erk and p38MAPK activity.

Clinical Trial

NCT Number	Sponsor	Condition	Start Date	Phase A549
NCT01329991	Plexxikon\|		2011-05	PHASE1

Chemical Information

CAS No. 295350-45-7
Molecular Weight 1459.09
Formula C₇₂H₉₆ClN₁₇O₁₄
Synonyms

D-63153
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (259 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Festuccia C, et al. Ozarelix, a fourth generation GnRH antagonist, induces apoptosis in hormone refractory androgen receptor negative prostate cancer cells modulating expression and activity of death receptors. Prostate. 2010 Sep 1;70(12):1340-9. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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