P-gp modulator-4
P-gp modulator-4 (compound 4c) inhibits the efflux function of P-glycoprotein (P-gp). P-gp modulator-4 shows multidrug resistance (MDR) in cancer reversal activity (IC50 of Paclitaxel (HY-B0015) = 8.80, reversal fold = 211.8).
For research use only. We do not sell to patients.
- Formula: C40H68N2O6
- Molecular Weight:672.98
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HK-2 | IC50 |
63.07 μM
Compound: 4c
|
Cytotoxicity against human HK-2 cells assessed as cell survival measured after 72 hrs incubation by MTT assay
Cytotoxicity against human HK-2 cells assessed as cell survival measured after 72 hrs incubation by MTT assay
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[PMID: 38704938] |
| HUVEC | IC50 |
>100 μM
Compound: 4c
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Cytotoxicity against HUVEC cells assessed as cell survival measured after 72 hrs incubation by MTT assay
Cytotoxicity against HUVEC cells assessed as cell survival measured after 72 hrs incubation by MTT assay
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[PMID: 38704938] |
Chemical Information
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Molecular Weight 672.98
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Formula C40H68N2O6
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SMILES
CC(C)(O)[C@H](O1)CC[C@@]1(C)[C@@]2([H])CC[C@@]3(C)[C@]4(C)CC[C@@]5([H])C(C)(C)[C@@H](NC(CC6CN(C(OC(C)(C)C)=O)C6)=O)CC[C@]5(C)[C@@]4([H])C[C@@H](O)[C@@]32[H]
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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