1. Inhibitory Antibodies
  2. Pascolizumab

Pascolizumab  (Synonyms: SB-240683)

Cat. No.: HY-P99801 Purity: ≥95.0%

Pascolizumab (SB-240683) is a humanized anti-IL-4 monoclonal antibody. Pascolizumab has the potential for the research of asthma.

For research use only. We do not sell to patients.

Pascolizumab Chemical Structure

Pascolizumab Chemical Structure

CAS No. : 331243-22-2

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Pascolizumab (SB-240683) is a humanized anti-IL-4 monoclonal antibody. Pascolizumab has the potential for the research of asthma[1].


Human IgG1 kappa

Recommend Isotype Controls


In Vitro

Pascolizumab binding of IL-4 inhibits IL-4 interaction with the alpha chain of the IL-4 receptor[1].
Pascolizumab (0-10000 pM; 3 days) shows anti-proliferative activity with IC50 values of 157, 377 pM for T-cell and Tonsil B-cell, respectively[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay[1]

Cell Line: human or monkey T cells
Concentration: 0-10000 pM
Incubation Time: 3 days
Result: Inhibited the response of human and monkey T cells to recombinant monkey IL-4 (2 ng/ml) with IC50 values of 268 pM and 587 pM, respectively.
Clinical Trial



Colorless to light yellow




Shipping with dry ice.


Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Purity: ≥95.0%

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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