Pascolizumab
Based on 1 Customer Validation
Pascolizumab (SB-240683) is a humanized anti-IL-4 monoclonal antibody. Pascolizumab has the potential for the research of asthma.
For research use only. We do not sell to patients.
- Purity : 99.09%
- CAS No.: 331243-22-2
- Molecular Weight:147.18 kDa
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Storage:Shipping with dry ice
Please store the product under the recommended conditions in the Certificate of Analysis.
Biological Activity
Description
Isotype
Human IgG1 kappa
Recommend Isotype Controls
Species Reactivity
Human
IC50 & Target
IL-4
In Vitro
Pascolizumab binding of IL-4 inhibits IL-4 interaction with the alpha chain of the IL-4 receptor[1].
Pascolizumab (0-10000 pM; 3 days) shows anti-proliferative activity with IC50 values of 157, 377 pM for T-cell and Tonsil B-cell, respectively[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:human or monkey T cells
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Concentration:0-10000 pM
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Incubation Time:3 days
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Result:Inhibited the response of human and monkey T cells to recombinant monkey IL-4 (2 ng/ml) with IC50 values of 268 pM and 587 pM, respectively.
Clinical Trial
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | 2011-05 | PHASE1 |
Gene ID
Accession
P05112-1
Conjugated
Unconjugated
Reconstitution
The product can be reconstituted/diluted with sterile PBS or saline.
Format
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Human IgG1 kappa
Application
ELISA, FACS, Functional assay
Verified Bioactivity
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Flow Cytometry analysis of Raji cells labelling IL-4 (red) with Pascolizumab (HY-P99801). Cells were fixed with 4% paraformaldehyde and permeabilised with 90% methanol. Then cells were stained with the primary antibody at 1/200 dilution for an hour at 4℃. Goat Anti-Human IgG H&L (AF488) (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. Human IgG1 Isotype Control (HY-P99001, blue) was used as the isotype control.
Chemical Information
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CAS No. 331243-22-2
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Appearance Liquid
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Molecular Weight 147.18 kDa
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Color Colorless to light yellow
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SMILES
[Pascolizumab]
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Synonyms
SB-240683
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Shipping
Shipping with dry ice.
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Formulation
Please refer to the lot-specific COA for specific buffer information.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
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Data Sheet (258 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Inhibitory Antibodies User Guide (603 KB)
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)