1. Inhibitory Antibodies
  2. Pascolizumab

Pascolizumab  (Synonyms: SB-240683)

Cat. No.: HY-P99801 Purity: ≥95.0%
COA

Pascolizumab (SB-240683) is a humanized anti-IL-4 monoclonal antibody. Pascolizumab has the potential for the research of asthma.

For research use only. We do not sell to patients.

Pascolizumab Chemical Structure

Pascolizumab Chemical Structure

CAS No. : 331243-22-2

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Description

Pascolizumab (SB-240683) is a humanized anti-IL-4 monoclonal antibody. Pascolizumab has the potential for the research of asthma[1].

Isotype

Human IgG1 kappa

Recommend Isotype Controls
Species

Humanized

In Vitro

Pascolizumab binding of IL-4 inhibits IL-4 interaction with the alpha chain of the IL-4 receptor[1].
Pascolizumab (0-10000 pM; 3 days) shows anti-proliferative activity with IC50 values of 157, 377 pM for T-cell and Tonsil B-cell, respectively[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay[1]

Cell Line: human or monkey T cells
Concentration: 0-10000 pM
Incubation Time: 3 days
Result: Inhibited the response of human and monkey T cells to recombinant monkey IL-4 (2 ng/ml) with IC50 values of 268 pM and 587 pM, respectively.
Clinical Trial
CAS No.
Appearance

Liquid

Color

Colorless to light yellow

SMILES

[Pascolizumab]

Shipping

Shipping with dry ice.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Purity: ≥95.0%

References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Pascolizumab
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HY-P99801
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