Petatewalide A
Petatewalide A is a bakkenolide-type sesquiterpene. Petatewalide A is isolated from Petasites tatewakianus. Petatewalide A inhibits NO production. Petatewalide A exhibits anticancer activity against cervical cancer, breast cancer, and Lewis lung cancer.
For research use only. We do not sell to patients.
- CAS No.: 1280717-80-7
- Formula: C22H30O6
- Molecular Weight:390.48
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HeLa | IC50 |
93.3 μM
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Cytotoxicity against human cervical carcinoma HeLa cells assessed by MTT assay, with cell viability measured after exposure to the compound.
Cytotoxicity against human cervical carcinoma HeLa cells assessed by MTT assay, with cell viability measured after exposure to the compound.
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19686812 |
| MCF7 | IC50 |
114.3 μM
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Cytotoxicity against human breast cancer MCF-7 cells assessed by MTT assay, with cell viability measured after exposure to the compound.
Cytotoxicity against human breast cancer MCF-7 cells assessed by MTT assay, with cell viability measured after exposure to the compound.
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19686812 |
| BV-2 | IC50 |
84.1 μM
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Inhibition of LPS-induced NO production in murine microglial BV-2 cells assessed by Griess reaction after incubation for 20 hrs.
Inhibition of LPS-induced NO production in murine microglial BV-2 cells assessed by Griess reaction after incubation for 20 hrs.
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25188451 |
In Vitro
Petatewalide A exhibits weak cytotoxic activity against the HeLa, MCF-7, and LLC cancer cell lines, with the most potent effect against the LLC cell line (IC50 = 77.9 μM)[1].
Petatewalide A (20 h) moderately inhibits LPS-induced NO production in murine microglial BV-2 cells with an IC50 value of 84.1 μM[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 1280717-80-7
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Molecular Weight 390.48
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Formula C22H30O6
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SMILES
O(C(C)=O)[C@H]1[C@@]2(C[C@@]3(C)[C@@]1([C@@H](OC(C=C(C)C)=O)CC[C@@H]3C)[H])C(=C)COC2=O
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Dong XW, et al. Bakkenolides from Petasites tatewakianus. Fitoterapia. 2010 Apr;81(3):153-6. [Content Brief]
[2]. Wang M, et al. Characterization and NO inhibitory activities of chemical constituents from an edible plant Petasites tatewakianus. Journal of agricultural and food chemistry. 2014 Sep 24;62(38):9362-7. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Petatewalide A Related Classifications
HY-N21762 Related Classifications
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