1. Anti-infection
  2. SARS-CoV
  3. Nirmatrelvir

Nirmatrelvir (Synonyms: PF-07321332)

Cat. No.: HY-138687 Purity: 99.83%
Handling Instructions

Nirmatrelvir (PF-07321332) is a potent and orally active SARS-CoV 3C-like protease (3CLPRO) inhibitor. Nirmatrelvir (PF-07321332) targets to the SARS-CoV-2 virus and can be used for COVID-19 research.

For research use only. We do not sell to patients.

Nirmatrelvir Chemical Structure

Nirmatrelvir Chemical Structure

CAS No. : 2628280-40-8

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply Now  
Solution
10 mM * 1 mL in DMSO USD 165 In-stock
Estimated Time of Arrival: December 31
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
USD 165 In-stock
Estimated Time of Arrival: December 31
Solid
5 mg USD 150 In-stock
Estimated Time of Arrival: December 31
10 mg USD 240 In-stock
Estimated Time of Arrival: December 31
50 mg USD 650 In-stock
Estimated Time of Arrival: December 31
100 mg USD 1100 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Customer Review

Based on 7 publication(s) in Google Scholar

Top Publications Citing Use of Products
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  • Purity & Documentation

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Description

Nirmatrelvir (PF-07321332) is a potent and orally active SARS-CoV 3C-like protease (3CLPRO) inhibitor. Nirmatrelvir (PF-07321332) targets to the SARS-CoV-2 virus and can be used for COVID-19 research[1].

IC50 & Target

IC50: 3CLPRO[1]

In Vitro

3CLPRO is responsible for cleaving polyproteins 1a and 1ab of SARS-CoV-2.1. Without the activity of the SARS-CoV-2 3CLPRO, nonstructural proteins (including proteases) cannot be released to perform their functions, inhibiting viral replication[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial
Molecular Weight

499.53

Formula

C23H32F3N5O4

CAS No.
SMILES

O=C(NCC1)[[email protected]@H]1C[[email protected]@H](C#N)NC([[email protected]@H]2[[email protected]]3([H])[[email protected]@](CN2C([[email protected]](C(C)(C)C)NC(C(F)(F)F)=O)=O)([H])C3(C)C)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 140 mg/mL (280.26 mM; Need ultrasonic)

Ethanol : 50 mg/mL (100.09 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.0019 mL 10.0094 mL 20.0188 mL
5 mM 0.4004 mL 2.0019 mL 4.0038 mL
10 mM 0.2002 mL 1.0009 mL 2.0019 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (4.16 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.08 mg/mL (4.16 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (4.16 mM); Clear solution

*All of the co-solvents are available by MCE.
References

Purity: 99.83%

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Nirmatrelvir
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HY-138687
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