2. Neuronal Signaling
  3. CaMK
  4. Ph-HTBA

Ph-HTBA is a high-affinity, brain-penetrating modulator for CaMKIIα. Ph-HTBA has binding affinity for CaMKIIα with a Kd value of 757 nM. Ph-HTBA can be used for the research of ischemia and neurodegenerative disorders.

For research use only. We do not sell to patients.

Ph-HTBA Chemical Structure

Ph-HTBA Chemical Structure

CAS No. : 2368927-41-5

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Ph-HTBA Related Antibodies

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Description

Ph-HTBA is a high-affinity, brain-penetrating modulator for CaMKIIα. Ph-HTBA has binding affinity for CaMKIIα with a Kd value of 757 nM. Ph-HTBA can be used for the research of ischemia and neurodegenerative disorders[1].

IC50 & Target

Kd: 757 nM (CaMKIIα)[1]
In Vitro

Ph-HTBA can inhibit HOCPCA binding with a Ki value of 1.4 μM[1].
Ph-HTBA has binding affinity for CaMKIIα with a Kd value of 757 nM[1].
Ph-HTBA (compound 1i) has a marked hub thermal stabilization effect along with a distinct CaMKIIα Trp403 flip upon binding[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Ph-HTBA Related Antibodies
In Vivo

Ph-HTBA has good cellular permeability and low microsomal clearance and shows brain permeability after systemic administration to mice[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

294.34

Formula

C19H18O3
CAS No.
SMILES

O=C(O)/C=C1CCCC2=CC(C3=CC=CC=C3)=CC=C2C\1O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Ph-HTBA Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Ph-HTBA2368927-41-5CaMKCalmodulin-dependent protein kinasesCalmodulin-dependent kinasesaffinitybrain-penetratingmodulatorCaMKIIαAlzheimerParkinson diseaseneurodegenerative disorderischemiaInhibitorinhibitorinhibit

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