2. Cell Cycle/DNA Damage Epigenetics Apoptosis Protein Tyrosine Kinase/RTK
  3. Aurora Kinase c-Myc Bcr-Abl Histone Methyltransferase Apoptosis
  4. PHA-680626

PHA-680626 is an effective inhibitor of the interaction between Aurora-A and N-Myc. PHA-680626 inhibits kinase activity of AURKA and Bcr-Abl, and induces N-Myc degradation. PHA-680626 decreases phosphorylation of CrkL and histone H3. PHA-680626 shows anti-proliferative and pro-apoptotic activity on Imatinib (HY-15463)-resistant chronic myeloid leukemia cell lines and primary CD34+ cells.

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PHA-680626

PHA-680626 Chemical Structure

CAS No. : 398493-74-8

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PHA-680626 Related Antibodies

Top Publications Citing Use of Products

Voir tous les produits spécifiques à Isoform Aurora Kinase:

Voir toutes les isoformes
Aurora Kinase Aurora A Aurora B Aurora C

Voir tous les produits spécifiques à Isoform Bcr-Abl:

Voir toutes les isoformes
Abl Bcr-Abl

Voir tous les produits spécifiques à Isoform Histone Methyltransferase:

Voir toutes les isoformes
EZH1 EZH2 DOT1L SMYD2 SMYD3 SUV39H2/KMT1B EHMT2/G9a/KMT1C EHMT1/GLP/KMT1D ASH1L/KMT2H SETDB1/KMT2G SETD2/KMT3A NSD2/MMSET/WHSC1 NSD3/WHSC1L1 SETD7/KMT7 SETD8/KMT5A PRMT1 PRMT3 PRMT4 PRMT5 PRMT6 PRMT7 PRMT8

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Description

PHA-680626 is an effective inhibitor of the interaction between Aurora-A and N-Myc. PHA-680626 inhibits kinase activity of AURKA and Bcr-Abl, and induces N-Myc degradation. PHA-680626 decreases phosphorylation of CrkL and histone H3. PHA-680626 shows anti-proliferative and pro-apoptotic activity on Imatinib (HY-15463)-resistant chronic myeloid leukemia cell lines and primary CD34+ cells[1].

Cellular Effect
Cell Line Type Value Description References
HCT-116 IC50
0.57 μM
Compound: 28
Antiproliferative activity against human HCT116 cells assessed as BrdU incorporation after 72 hrs
Antiproliferative activity against human HCT116 cells assessed as BrdU incorporation after 72 hrs
[PMID: 19320489]
Masse moléculaire

450.56

Formule

C23H26N6O2S
CAS No.
SMILES

O=C(NC1=NNC2=C1CN(C(CC3=CC=CS3)=O)C2)C4=CC=C(N5CCN(C)CC5)C=C4
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
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PHA-680626 Related Classifications

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Keywords:

PHA-680626398493-74-8PHA680626PHA 680626Aurora Kinasec-MycBcr-AblHistone MethyltransferaseApoptosisMycanti-proliferativepro-apoptoticImatinib-resistantCMLInhibitorinhibitorinhibit

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HY-125090
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