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Cat. No.: HY-153512

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PHD-1-IN-3

PHD-1-IN-3 is an orally active PHD-1 inhibitor with an IC₅₀ of 0.09 μM. PHD-1-IN-3 acts via monodentate binding interaction with active site Fe²⁺ ion.

For research use only. We do not sell to patients.

CAS No.: 2009345-20-2
Formula: C₁₄H₁₁N₅
Molecular Weight:249.28

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

PHD-1-IN-3 Chemical Structure

CAS No.: 2009345-20-2

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
- Parmacokinetics
Chemical Information
Purity & Documentation
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Biological Activity

Description

PHD-1-IN-3 is an orally active PHD-1 inhibitor with an IC₅₀ of 0.09 μM. PHD-1-IN-3 acts via monodentate binding interaction with active site Fe²⁺ ion^[1].

All HIF/HIF Prolyl-Hydroxylase Isoforms :

In Vitro

PHD-1-IN-3 (compound 53) acts as an MDR1 substrate in MDR1-MDCK cell monolayers^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Parmacokinetics

Species	Dose	Route	CL	AUC_0-t	C_max	F
Mice^[1]	3 mg/kg	p.o.	/	40038 ng·h/mL	14.8 μM	39 %
Mice^[1]	0.5 mg/kg	i.v.	0.48 mL/min/kg	/	/	/

Chemical Information

CAS No. 2009345-20-2
Molecular Weight 249.28
Formula C₁₄H₁₁N₅
SMILES

N#CC=1C=CC(C2=CC(N)=CC3=NC=NN32)=C(C1)C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Ahmed S, et al. 1,2,4-Triazolo-[1,5-a]pyridine HIF Prolylhydroxylase Domain-1 (PHD-1) Inhibitors With a Novel Monodentate Binding Interaction. J Med Chem. 2017;60(13):5663-5672. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
References

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PHD-1-IN-3

All HIF/HIF Prolyl-Hydroxylase Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

PHD-1-IN-3 Related Classifications

HY-153512 Related Classifications