2. Metabolic Enzyme/Protease
  3. HIF/HIF Prolyl-Hydroxylase
  4. PHD-1-IN-4

PHD-1-IN-4 is a brain-penetrant PHD-1 inhibitor with an IC50 of 0.074 μM.

For research use only. We do not sell to patients.

PHD-1-IN-4

PHD-1-IN-4 Chemical Structure

CAS No. : 2009343-19-3

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
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Solution
10 mM * 1 mL in DMSO In-stock
Solid
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PHD-1-IN-4 Related Antibodies

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HIF-1α HIF PHD1

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Description

PHD-1-IN-4 is a brain-penetrant PHD-1 inhibitor with an IC50 of 0.074 μM[1].

In Vitro

PHD-1-IN-4 (Compound 39) potently inhibits purified PHD-1 enzyme with an IC50 of 0.074 μM[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

PHD-1-IN-4 Related Antibodies
Parmacokinetics
Species Dose Route CL AUC Cmax F B/P
Mice[1] 3 mg/kg p.o. / 1869 ng·h/mL 5.58 μM 100 % 0.88
Mice[1] 0.5 mg/kg i.v. 31.6 mL/min/kg / / / /
Molecular Weight

234.26

Formula

C14H10N4
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

N#CC=1C=CC(C2=CC=CC3=NC=NN32)=C(C1)C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (213.44 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.2688 mL 21.3438 mL 42.6876 mL
5 mM 0.8538 mL 4.2688 mL 8.5375 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 4.2688 mL 21.3438 mL 42.6876 mL 106.7190 mL
5 mM 0.8538 mL 4.2688 mL 8.5375 mL 21.3438 mL
10 mM 0.4269 mL 2.1344 mL 4.2688 mL 10.6719 mL
15 mM 0.2846 mL 1.4229 mL 2.8458 mL 7.1146 mL
20 mM 0.2134 mL 1.0672 mL 2.1344 mL 5.3360 mL
25 mM 0.1708 mL 0.8538 mL 1.7075 mL 4.2688 mL
30 mM 0.1423 mL 0.7115 mL 1.4229 mL 3.5573 mL
40 mM 0.1067 mL 0.5336 mL 1.0672 mL 2.6680 mL
50 mM 0.0854 mL 0.4269 mL 0.8538 mL 2.1344 mL
60 mM 0.0711 mL 0.3557 mL 0.7115 mL 1.7787 mL
80 mM 0.0534 mL 0.2668 mL 0.5336 mL 1.3340 mL
100 mM 0.0427 mL 0.2134 mL 0.4269 mL 1.0672 mL
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PHD-1-IN-4 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PHD-1-IN-42009343-19-3HIF/HIF Prolyl-HydroxylaseHypoxia-inducible factorsHIFsHIF-PHMDR1PHD-1MDR1-MDCK cell monolayers1,2,4-triazolo-pyridine scaffoldmale C57BL/6 miceInhibitorinhibitorinhibit

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