2. Immunology/Inflammation NF-κB Metabolic Enzyme/Protease
  3. Reactive Oxygen Species
  4. Phycocyanobilin

Phycocyanobilin, an orally active antioxidative agent, is an effective scavenger for various reactive oxygen species. Phycocyanobilin can be used for the research of Alzheimer’s disease.

For research use only. We do not sell to patients.

Phycocyanobilin Chemical Structure

Phycocyanobilin Chemical Structure

CAS No. : 20298-86-6

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Phycocyanobilin Related Antibodies

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  • Biological Activity

  • Purity & Documentation

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Description

Phycocyanobilin, an orally active antioxidative agent, is an effective scavenger for various reactive oxygen species. Phycocyanobilin can be used for the research of Alzheimer’s disease[1][2][3].

In Vitro

Phycocyanobilin (100 μM; 0-250 min) inhibits the peroxidation of methyl linoleate and produces a prolonged induction period[1].
Phycocyanobilin (1 mM; 0-300 min) suppresses the oxidation of the liposomes[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Phycocyanobilin Related Antibodies
In Vivo

Phycocyanobilin (15 mg/kg; p.o.; in diet for 2 weeks) shows antioxidant effects in type 2 diabetes mice[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male C57BL/Ks J db/db mice, a rodent model for type 2 diabetes[3]
Dosage: 15 mg/kg
Administration: In diet for 2 weeks
Result: Significantly decreased blood glucose levels. Normalized the increases in urinary 8-OHdG and 8-epi-PGF2α levels, renal oxidative stress markers evaluated by renal 8-OHdG staining and DHE staining, Nox4 mRNA, and protein expression, as well as the mRNA levels of other NAD(P)H oxidase components, inflammatory markers and HO-1.
Molecular Weight

586.68

Formula

C33H38N4O6
CAS No.
Appearance

Solid

Color

Green to dark green

SMILES

O=C(NC/1=C\C2=C(C)C(CCC(O)=O)=C(/C=C3C(CCC(O)=O)=C(C(/C=C(C(C)=C4CC)\NC4=O)=N/3)C)N2)[C@H](C)C1=C\C
Structure Classification
Initial Source

Spirulina platensis
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : < 1 mg/mL (insoluble or slightly soluble)

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

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Volume (start)

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Concentration (final)

C2

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Volume (final)

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In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  Tris-HCl buffer

    Solubility: 5.88 mg/mL (10.02 mM); Suspended solution; Need ultrasonic

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  PBS

    Solubility: 10 mg/mL (17.05 mM); Suspended solution; Need ultrasonic

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

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Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
%
DMSO +
% 
+
%
Tween-80 +
%
Saline
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Calculation results:
Working solution concentration: mg/mL
Method for preparing stock solution: mg drug dissolved in μL  DMSO (Stock solution concentration: mg/mL).

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.
 If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation

Purity: ≥99.0%

COA (257 KB)

Handling Instructions (2659 KB)
References
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Phycocyanobilin Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Phycocyanobilin20298-86-6Reactive Oxygen Speciesantioxidanttype 2 diabetesAlzheimer’s diseaseNAD(P)Hsuperoxide productionInhibitorinhibitorinhibit

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