2. Membrane Transporter/Ion Channel
  3. P-glycoprotein
  4. PID-9

PID-9 is a P-glycoprotein inhibitor. PID-9 has multidrug resistance (MDR) reversal activity (IC50 = 0.1338 μM) and low toxicity. PID-9 inhibits the transport function of P-gp without downregulating P-gp expression.

For research use only. We do not sell to patients.

PID-9 Chemical Structure

PID-9 Chemical Structure

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PID-9 Related Antibodies

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Description

PID-9 is a P-glycoprotein inhibitor. PID-9 has multidrug resistance (MDR) reversal activity (IC50 = 0.1338 μM) and low toxicity. PID-9 inhibits the transport function of P-gp without downregulating P-gp expression[1].

In Vitro

PID-9 (2.5 μM) increases the intracellular accumulation of Doxorubicin (HY-15142) (10 μM) in the drug-resistant SW620/AD300 cells, and increases Doxorubicin-induced apoptosis[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

PID-9 Related Antibodies
Molecular Weight

824.02

Formula

C50H57N5O6
SMILES

O=C(NC1=CC=C(CCN2CC3=C(C=C(OC)C(OC)=C3)CC2)C=C1)C4=CC=CC=C4NC(C5=CC=C(C(N6CCN(C(CC78C[C@@]9([H])CC(C8)CC(C9)C7)=O)CC6)=O)C=C5)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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PID-9 Related Classifications

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PID-9PID9PID 9P-glycoproteinP-gpPgpMultidrug resistance protein 1MDR1ATP-binding cassette sub-family B member 1ABCB1Cluster of differentiation 243CD243p-gpmultidrug resistanceMDRInhibitorinhibitorinhibit

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PID-9
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HY-162369
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