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Cat. No.: HY-P99887

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Biologically Validated

Pimivalimab

Name: Pimivalimab
Brand: MedChemExpress
SKU: HY-P99887
Price: 500.00 USD
Availability: InStock
Rating: 5 (1 reviews)

(Synonyms: JTX-4014)

Avis client

Based on 1 Customer Validation

Pimivalimab (JTX-4014) is an anti-PD-1 IgG4 monoclonal antibody. Pimivalimab binds to PD-1, blocking its interaction with PD-L1 and PD-L2, and enhances antitumor immune activity. Pimivalimab can be used for research on advanced or metastatic renal cell carcinoma and metastatic non-small cell lung cancer.

Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.

CAS No.: 2293951-22-9
Masse moléculaire:144.9 kDa

Stockage:

Shipping with dry ice

Please store the product under the recommended conditions in the Certificate of Analysis.

Pimivalimab Chemical Structure

CAS No.: 2293951-22-9

Size

Prix

Stock

Quantité

Amount: USD 0.00

* Veuillez sélectionner la quantité avant d'ajouter des articles.

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- Isotype
- Recommend Isotype Controls
- Species Reactivity
- IC₅₀ & Target
- In Vitro
- Essai clinique
- Gene ID
- Accession
- Conjugated
- Reconstitution
- Format
- Application
- Verified Bioactivity
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
Bioz

Activité biologique

Description

Isotype

Human IgG4 kappa

Recommend Isotype Controls

Human IgG4 (S228P) kappa, Isotype Control

Species Reactivity

Human

IC₅₀ & Target

PDCD1/PD-1/CD279

In Vitro

Immune Tolerance and ImmunosuppressionAnti-cancer

Immune Tolerance and Immunosuppression

Anti-cancer

Pimivalimab (JTX-4014) is a fully human IgG4 monoclonal antibody targeting PD-1. The IgG4 subtype is selected to reduce antibody-dependent cell-mediated cytotoxicity or complement-dependent cytotoxicity against normal effector T cells expressing PD-1, thereby protecting anti-tumor immune cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Essai clinique

NCT Number	Sponsor	Condition	Start Date	Phase A549
NCT01329991			2011-05	PHASE1

Gene ID

5133 [NCBI]

Accession

Q15116

Conjugated

Unconjugated

Reconstitution

The product can be reconstituted/diluted with sterile PBS or saline.

Format

Human IgG4 kappa

Application

ELISA, FACS, Functional assay

Verified Bioactivity

Immobilized PD-1 Protein, Human (143a.a, HEK293, His, HY-P7396) can bind Pimivalimab. The EC₅₀ for this effect is 4.21 ng/mL.

Chemical Information

CAS No. 2293951-22-9
Appearance Liquid
Masse moléculaire 144.9 kDa
Color Colorless to light yellow
SMILES

[Pimivalimab]
Synonyms

JTX-4014
Livraison

Shipping with dry ice.
Formulation

Please refer to the lot-specific COA for specific buffer information.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (267 KB)
SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Inhibitory Antibodies User Guide (603 KB)

Références

[1]. Lara Jr P N, et al. Leukocyte immunoglobulin-like receptor (LILRB2)-targeted JTX-8064 plus the anti-PD1 inhibitor JTX-4014 (pimivalimab) in immune-checkpoint inhibitor (ICl) pretreated patients (pts) with advanced or metastatic renal cell cancer (mRCC): Results from the multi-stage phase 1-2 INNATE trial[J]. 2024.

[2]. Feng Y, et al. Target neutrophil heterogeneity and plasticity in cancer. Journal of hematology & oncology. 2025 Aug 12;18(1):79.

[3]. Papadopoulos KP, et al. Phase I, first-in-human trial of programmed cell death receptor-1 (PD-1) inhibitor, JTX-4014, in adult patients with advanced, refractory, solid tumors. Cancer Immunol Immunother. 2021 Mar;70(3):763-772.

[4]. Kobziev O, et al. Phase 2 study of PD-1 inhibitor JTX-4014 alone and in combination with vopratelimab, an ICOS agonist, in biomarker-selected subjects with metastatic NSCLC after one prior platinum-containing regimen (SELECT)[J]. 2021.

Calculators

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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Amount: USD 0.00

Activité biologique
- Description
- Isotype
- Recommend Isotype Controls
- Species Reactivity
- IC₅₀ & Target
- In Vitro
- Essai clinique
- Gene ID
- Accession
- Conjugated
- Reconstitution
- Format
- Application
- Biological Activity
Chemical Information
Pureté et documentation
Références

Nom du produit:
Cat. No.:
Quantité:
MCE Japan Authorized Agent:

Nom du produit:
CAS No.:
Species:
Pureté:
Quantité:

Pimivalimab

HOLO Human Interleukin-2 (IL-2) Detection Kit

Protein A Agarose

Bradford Protein Assay Kit

DPBS Buffer (1×)

PBS Buffer (1×)

Cytotoxicity LDH Assay Kit