2. Cell Cycle/DNA Damage Cytoskeleton
  3. Microtubule/Tubulin
  4. PK-3

PK-3 is a cancer cell growth inhibitor with microtubule-binding activity. PK-3 binds to tubulin, disrupts the intracellular microtubule network required for mitosis, and induces cell death. PK-3 can be used in research related to chronic myeloid leukemia.

For research use only. We do not sell to patients.

PK-3

PK-3 Chemical Structure

CAS No. : 932331-38-9

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PK-3 Related Antibodies

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Description

PK-3 is a cancer cell growth inhibitor with microtubule-binding activity. PK-3 binds to tubulin, disrupts the intracellular microtubule network required for mitosis, and induces cell death. PK-3 can be used in research related to chronic myeloid leukemia[1].

In Vitro

PK-3 (18-55 nM; 10 to 21 days) induces a form of non-apoptotic cell death that is distinct from ferroptosis in KBM7 cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

PK-3 Related Antibodies

Cell Viability Assay[1]

Cell Line: human chronic myeloid leukemia KBM7 cells
Concentration: 55 nM (initial screening for colony outgrowth); 18 nM (final estimated after 3-day initial incubation with growth medium dilution)
Incubation Time: 10 to 21 days
Result: Induced a non-ferroptotic form of non-apoptotic cell death in KBM7 cells.
Yielded no significantly enriched genes with gene trap insertions in PK-3-resistant KBM7 colonies.
Molecular Weight

380.46

Formula

C21H20N2O3S
CAS No.
SMILES

O=S(N1CCCC2=C1C=CC=C2)(C3=CC=C(C=C3)C4=CN=C(O4)C5CC5)=O
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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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PK-3 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PK-3932331-38-9PK3PK 3Microtubule/Tubulincancer cell growth inhibitorchronic myeloid leukemiaInhibitorinhibitorinhibit

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