Pladienolide A
Based on 1 Customer Validation
Pladienolide A is a natural product derived from Streptomyces platensis. Pladienolide A inhibits hypoxia-induced VEGF promoter-driven PLAP reporter gene. Pladienolide A can be used for research on glioma.
Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.
- Pureté : 98.01%
- CAS No.: 445493-22-1
- Formule: C28H46O7
- Masse moléculaire:494.66
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Stockage:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
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Solvant et solubilité
- Pureté et documentation
- Références
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Help & FAQs
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Activité biologique
Description
In Vitro
Pladienolide A (967.5 nM; 72 h) inhibits U251 human glioma cell proliferation with an IC50 of 967.5 nM[2].
Pladienolide A (451.5 nM; 18 h) inhibits hypoxia-induced VEGF-PLAP secretion in U251 VEGF-PLAP reporter cells with an IC50 of 451.5 nM[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 445493-22-1
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Appearance Solid
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Masse moléculaire 494.66
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Formule C28H46O7
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Color Off-white to light yellow
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SMILES
C/C([C@@H]1[C@H](/C=C/[C@@H]([C@](O)(CC[C@H](CC(O1)=O)O)C)O)C)=C\C=C\[C@@H](C)C[C@@H]2[C@@](O2)([H])[C@H](C)[C@@H](O)CC
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Structure Classification
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Initial Source
Streptomyces platensis
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Solvant et solubilité
In Vitro:
DMSO : 5 mg/mL (10.11 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureté et documentation
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Fiche technique (271 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Instruction de manipulation (2659 KB)
Références
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.0216 mL | 10.1080 mL | 20.2159 mL | 50.5398 mL |
| 5 mM | 0.4043 mL | 2.0216 mL | 4.0432 mL | 10.1080 mL | |
| 10 mM | 0.2022 mL | 1.0108 mL | 2.0216 mL | 5.0540 mL |
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