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Cat. No.: HY-142073

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(+)-Dihydrocalanolide A

(Synonyms: DHCal A; NSC 678323)

(+)-Dihydrocalanolide A (DHCal A; NSC 678323) is an orally active nonnucleoside inhibitor of Reverse Transcriptase. (+)-Dihydrocalanolide A can be used to HIV infection research.

For research use only. We do not sell to patients.

CAS No.: 183904-53-2
Formula: C₂₂H₂₈O₅
Molecular Weight:372.45

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (274 KB)

(+)-Dihydrocalanolide A Chemical Structure

CAS No.: 183904-53-2

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Biological Activity
- Description
- Cellular Effect
- In Vivo
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Bioz

Biological Activity

Description

(+)-Dihydrocalanolide A (DHCal A; NSC 678323) is an orally active nonnucleoside inhibitor of Reverse Transcriptase. (+)-Dihydrocalanolide A can be used to HIV infection research^[1].

All HIV Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
CEM-SS	EC₅₀	0.2 μM Compound: 6	Using the XTT assay for cell viability, effective concentration to protect human lymphoblastoid CEM-SS cells from the cytopathic effects of HIV-1 (RF strain) was determined Using the XTT assay for cell viability, effective concentration to protect human lymphoblastoid CEM-SS cells from the cytopathic effects of HIV-1 (RF strain) was determined	[PMID: 8893846]
CEM-SS	IC₅₀	5.2 μM Compound: 6	Using the XTT assay for cell viability, inhibitory concentration to protect human lymphoblastoid CEM-SS cells from the cytopathic effects of HIV-1 (RF strain) was determined Using the XTT assay for cell viability, inhibitory concentration to protect human lymphoblastoid CEM-SS cells from the cytopathic effects of HIV-1 (RF strain) was determined	[PMID: 8893846]

In Vivo

(+)-Dihydrocalanolide A (25 mg/kg; p.o.; single dose) shows good pharmacokinetic parameters, with oral bioavailability in CD2F1 mice of 64%^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 183904-53-2
Molecular Weight 372.45
Formula C₂₂H₂₈O₅
SMILES

CCCC(C1=C(O2)C3=C(O[C@@H]([C@H]([C@@H]3O)C)C)C4=C1OC(C)(CC4)C)=CC2=O
Synonyms

DHCal A; NSC 678323
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (274 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Newman RA, et al. Pharmaceutical properties of related calanolide compounds with activity against human immunodeficiency virus. J Pharm Sci. 1998 Sep;87(9):1077-80. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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