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Cat. No.: HY-189507

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POI ligand-6

POI ligand-6 is a target protein ligand targeting HDAC6. POI ligand-6 can be used to synthesize the hydrophobic tag (Hyt) degrader HDAC6 degrader-6 (HY-189299). POI ligand-6 can be used for research on leukemia.

For research use only. We do not sell to patients.

CAS No.: 233587-95-6
Formula: C₁₄H₂₁N₃O₃
Molecular Weight:279.33

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

POI ligand-6 Chemical Structure

CAS No.: 233587-95-6

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- Cellular Effect
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

IC₅₀ & Target

^[1]

HDAC6

All HDAC Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
MOLT-4	IC50	0.18 μM	Antiproliferative activity against human MOLT-4 leukemia cells assessed as reduction in cell viability incubated for 48 hrs by tetramethyl azole blue colorimetric method. Antiproliferative activity against human MOLT-4 leukemia cells assessed as reduction in cell viability incubated for 48 hrs by tetramethyl azole blue colorimetric method.	42556264
K562	IC50	0.76 μM	Antiproliferative activity against human K562 leukemia cells assessed as reduction in cell viability incubated for 48 hrs by tetramethyl azole blue colorimetric method. Antiproliferative activity against human K562 leukemia cells assessed as reduction in cell viability incubated for 48 hrs by tetramethyl azole blue colorimetric method.	42556264

Chemical Information

CAS No. 233587-95-6
Molecular Weight 279.33
Formula C₁₄H₂₁N₃O₃
SMILES

ONC(CCCCCCC(NC1=CC=C(N)C=C1)=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Wang C, et al. Artemisinin-derived hydrophobic tags: structural modification and structure-activity relationship exploration of HDAC6/1 targeting degraders with potent antileukemic efficacy. Bioorganic chemistry. 2026 Oct 05;181:110275.

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biological Activity
- Description
- IC₅₀ & Target
Chemical Information
Purity & Documentation
References

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POI ligand-6

All HDAC Isoforms

Biological Activity

Description

IC50 & Target

Cellular Effect

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

POI ligand-6 Related Classifications

HY-189507 Related Classifications

Bioz

Keywords

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