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Cat. No.: HY-D1005J

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Poloxamer L62

Poloxamer L62 is a nonionic polyoxyethylene-polyoxypropylene block copolymer triblock surfactant. Poloxamer L62 interacts with the surfactant-liposome bilayer, causing minimal membrane disruption. Poloxamer L62 exhibits a decrease in critical micelle temperature, critical micelle concentration, and cloud point in ionic liquids, with minimal effect on micelle morphology. Within the tested surfactant concentration range, Poloxamer L62 has minimal effect on the release of encapsulated ciprofloxacin (Ciprofloxacin) (HY-B0356). Poloxamer L62 does not significantly alter the vesicle size of liposomal ciprofloxacin formulations.

For research use only. We do not sell to patients.

CAS No.: 9003-11-6
Molecular Weight:12600 (Average)

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (269 KB)

Poloxamer L62 Chemical Structure

CAS No.: 9003-11-6

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

In Vitro

Poloxamer L62 (1 × 10^-6 M) shows a surface tension inflection point at the air-water interface, occupying 64 Å² per molecule^[1].
Poloxamer L62 (2.4 g/100 mL) shows a benzopurpurine absorption inflection point and an iodine absorption inflection point^[1].
Poloxamer L62 (10% aqueous solution) has a cloud point of 32°C, and dual cloud points at 24 and 32°C have been reported^[1].
Poloxamer L62 (0.01-1.0% w/v; ≥ 30 min) does not significantly change the encapsulation efficiency of Ciprofloxacin in 12.5 mg/mL CFI liposomes under hypotonic conditions (release rate ≤ 1%-2%)^[3].
Poloxamer L62 (0.01-1.0% w/v; 5 min) does not change the mean vesicle size of 12.5 mg/mL CFI liposomes, which remains approximately 93 nm^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 9003-11-6
Molecular Weight 12600 (Average)
SMILES

CC.[H(OCH2CH2)x(OCH2CH)y(OCH2CH2)zOH].[CH3]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (269 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Krishna N Prasad, et al. Surface activity and association of ABA polyoxyethylene—polyoxypropylene block copolymers in aqueous solution,
Journal of Colloid and Interface Science, Volume 69, Issue 2, 1979, Pages 225-232, ISSN 0021-9797.

[2]. Roderick Stewart, et al. The behaviour and control of poloxamer activity in aqueous solution: polymer assembly, impact of bulk composition and tuneable nano formulation design, Pharmaceutics and Pharmacology, Volume 5, Issue 1, January 2026, rqag005.

[3]. Cipolla D, et al. Modifying the release properties of liposomes toward personalized medicine. Journal of pharmaceutical sciences. 2014 Jun;103(6):1851-62. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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