PPARα/γ agonist 5
PPARα/γ agonist 5 is a dual PPARα/γ agonist with significant biological activity exhibited at low concentrations. The EC50 of PPARα/γ agonist 5 are 0.358μM and 1.21μM respectively, showing its potential in inhibiting type 2 diabetes and lipid metabolism disorders. PPARα/γ agonist 5 was selected for clinical development due to its high efficacy.
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- No. CAS: 849150-59-0
- Fòrmula: C24H23NO5S
- Peso molecular:437.51
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Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| BHK-21 | EC50 |
1.21 μM
Compound: (R)-2Aa
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Agonist activity at human PPARgamma expressed in BHK21 cells assessed as SEAP activity by luciferase reporter transactivation assay
Agonist activity at human PPARgamma expressed in BHK21 cells assessed as SEAP activity by luciferase reporter transactivation assay
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[PMID: 19349176] |
Chemical Information
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No. CAS 849150-59-0
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Peso molecular 437.51
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Fòrmula C24H23NO5S
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SMILES
OC([C@H](OC)CC1=C2C(C=CS2)=C(C=C1)OCCC3=C(C)OC(C4=CC=CC=C4)=N3)=O
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
PPARα/γ agonist 5 Related Classifications
HY-167950 Related Classifications
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