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Cat. No.: HY-174443

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PROTAC sEH degrader-2

PROTAC sEH degrader-2 is a PROTAC targeting degradation agent for soluble epoxide hydrolase (sEH) with pIC₅₀ values of the catalytic domain of 8.37 (human sEH-H) and 7.12 (mouce sEH-H). PROTAC sEH degrader-2 can be used for the research related to inflammation and neuroinflammation, such as Alzheimer's disease.
(Pink: sEH-H ligand (HY-174225); Blue: Cereblon ligand (HY-103597); Black: linker).

For research use only. We do not sell to patients.

Formula: C₅₄H₅₇F₄N₉O₁₃S
Molecular Weight:1148.14

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (268 KB)

PROTAC sEH degrader-2 Chemical Structure

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

PROTAC sEH degrader-2 is a PROTAC targeting degradation agent for soluble epoxide hydrolase (sEH) with pIC₅₀ values of the catalytic domain of 8.37 (human sEH-H) and 7.12 (mouce sEH-H). PROTAC sEH degrader-2 can be used for the research related to inflammation and neuroinflammation, such as Alzheimer's disease^[1]. (Pink: sEH-H ligand (HY-174225); Blue: Cereblon ligand (HY-103597); Black: linker).

IC₅₀ & Target^[1]

Cereblon

All PROTACs Isoforms :

In Vitro

PROTAC sEH degrader-2 (Compound 23) (0-10 μM, 1-24 h) shows high degradation potencies towards hsEH-H in the nanomolar range and the highest D_max (75%) after 18 h^[1].

PROTAC sEH degrader-2 (0.5-50 μM, 72 h) shows no significant toxicity in HepG2 cells^[1].

PROTAC sEH degrader-2 (300 nM) initiates the degradation of sEH in human primary M1 macrophages, primary murine hepatocytes and human isolated lung slices^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Immunofluorescence^[1]

Cell Line:

human primary M1 macrophages
Concentration:

300 nM
Incubation Time:

/
Result:

Significantly reduced the staining of sHE.

Western Blot Analysis^[1]

Cell Line:

Primary murine hepatocytes, human isolated lung slices
Concentration:

300 nM
Incubation Time:

18 h
Result:

Significantly inhibited the levels of sEH

Chemical Information

Molecular Weight 1148.14
Formula C₅₄H₅₇F₄N₉O₁₃S
SMILES

O=C(NCC1=C(C=C(C=C1)NS(=O)(CCCC2=CN(N=N2)CCOCCOCCOCCOCCNC(COC3=C(C(N(C4C(NC(CC4)=O)=O)C5=O)=O)C5=CC=C3)=O)=O)C(F)(F)F)C6=CC=C7N(C=CC7=C6)CC8=CC=CC(F)=C8
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (268 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Schönfeld J, et al. Structure-Based Design of PROTACS for the Degradation of Soluble Epoxide Hydrolase. J Med Chem. 2025 Jul 10;68(13):13728-13749. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References

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PROTAC sEH degrader-2

All PROTACs Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

PROTAC sEH degrader-2 Related Classifications

HY-174443 Related Classifications