MAPKAPK5/PRAK
MAPKAPK5, known as PRAK or MK5, is activated by p38 and additionally by atypical mitogen-activated protein kinases ERK3 and ERK4, which bind its carboxy-terminal region and relocalize the enzyme, a partnership unique among MAPK-activated kinases. MK5 phosphorylates small heat shock proteins and participates in actin remodeling and cell migration. Its tumor biology is notable: PRAK mediates oncogene-induced senescence in a p53-dependent manner, and MAPKAPK5 deletion enhances chemical carcinogenesis in mice, supporting tumor-suppressive activity. Behavioral studies have additionally linked the kinase to anxiety-related phenotypes, extending its reach beyond inflammation into organismal physiology.
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MAPKAPK5/PRAK Recombinant Proteins (3)
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Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- Formula: Human
- Molecular Weight: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
