2. GPCR/G Protein Neuronal Signaling
  3. Cannabinoid Receptor
  4. PSB-KK1415

PSB-KK1415 is a selective agonist for human orphan G protein-coupled receptor GPR18, with EC50 of 19.1 nM.

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PSB-KK1415

PSB-KK1415 Chemical Structure

CAS No. : 885896-26-4

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
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Solution
10 mM * 1 mL in DMSO In-stock
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PSB-KK1415 Related Antibodies

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Description

PSB-KK1415 is a selective agonist for human orphan G protein-coupled receptor GPR18, with EC50 of 19.1 nM[1].

IC50 & Target

IC50: 19.1 nM (GPR18)
Molecular Weight

462.93

Formula

C24H23ClN6O2
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

CN1C2=C(C(N(C1=O)C)=O)N(C(NCCC3=CNC4=C3C=CC=C4)=N2)CC5=CC=C(C=C5)Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (216.02 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.1602 mL 10.8008 mL 21.6015 mL
5 mM 0.4320 mL 2.1602 mL 4.3203 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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(per animal)

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Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.92%

SDS (251 KB)

COA (255 KB) HNMR (225 KB) LCMS (118 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.1602 mL 10.8008 mL 21.6015 mL 54.0038 mL
5 mM 0.4320 mL 2.1602 mL 4.3203 mL 10.8008 mL
10 mM 0.2160 mL 1.0801 mL 2.1602 mL 5.4004 mL
15 mM 0.1440 mL 0.7201 mL 1.4401 mL 3.6003 mL
20 mM 0.1080 mL 0.5400 mL 1.0801 mL 2.7002 mL
25 mM 0.0864 mL 0.4320 mL 0.8641 mL 2.1602 mL
30 mM 0.0720 mL 0.3600 mL 0.7201 mL 1.8001 mL
40 mM 0.0540 mL 0.2700 mL 0.5400 mL 1.3501 mL
50 mM 0.0432 mL 0.2160 mL 0.4320 mL 1.0801 mL
60 mM 0.0360 mL 0.1800 mL 0.3600 mL 0.9001 mL
80 mM 0.0270 mL 0.1350 mL 0.2700 mL 0.6750 mL
100 mM 0.0216 mL 0.1080 mL 0.2160 mL 0.5400 mL
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PSB-KK1415 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PSB-KK1415885896-26-4Cannabinoid ReceptorselectiveCB1 likeInhibitorinhibitorinhibit

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