Anti-HIV and antiplasmodial activity of original flavonoid derivatives

  • Bioorg Med Chem. 2010 Aug 15;18(16):6012-23. doi: 10.1016/j.bmc.2010.06.067.
Gilles Casano  1 ,  Aurélien Dumètre ,  Christophe Pannecouque ,  Sébastien Hutter ,  Nadine Azas ,  Maxime Robin
Affiliations
  • 1. Aix-Marseille Université, Institut des Sciences Moléculaires de Marseille, iSm2-UMR CNRS, Centre Saint Jérôme, Marseille Cedex 20, France.
PMID: 20638854 DOI: 10.1016/j.bmc.2010.06.067
Abstract

In our search for potent anti-HIV and antiplasmodial agents, novel series of flavonoid derivatives and their chalcone intermediates were synthesized and evaluated for inhibition of HIV multiplication and antiproliferative activity on Plasmodium falciparum parasites. Chalcones exhibited a more selective antiplasmodial activity than Flavonoids. Methoxyflavone 7e was the only one compound active in both P. falciparum and HIV-1 whereas aminomethoxyflavones showed activity against HIV-2. Para substitution on the B ring seemed to increase HIV-2 potency.