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Cat. No.: HY-162413

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(R)-LW-Srci-8

(R)-LW-Srci-8 is a selective covalent inhibitor of c-Src (IC₅₀= 35.83 nM) that disrupts the autophosphorylation of c-Src by targeting its autophosphorylation site (Y419).

For research use only. We do not sell to patients.

Formula: C₁₉H₂₂F₂N₂O₂
Molecular Weight:348.39

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (270 KB)

(R)-LW-Srci-8 Chemical Structure

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Protocols (1)
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

(R)-LW-Srci-8 is a selective covalent inhibitor of c-Src (IC₅₀= 35.83 nM) that disrupts the autophosphorylation of c-Src by targeting its autophosphorylation site (Y419)^[1].

IC₅₀ & Target

IC50: 35.83 (c?Src)^[1].

All Src Isoforms :

In Vitro

MDA-MB-468 (5-20 μM; 3 h) inhibites the phosphorylation of c-Src at Y419 and STAT3 at Y705 in a dose-dependent manner in MDA-MB-468 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.

Chemical Information

Molecular Weight 348.39
Formula C₁₉H₂₂F₂N₂O₂
SMILES

FC1=CC([C@@H](N(C2CC2)C(C=C)=O)C(NC3CCCC3)=O)=CC(F)=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Protocols

All Cell Biology

Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (270 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Zhang H, et al. Discovery of a Covalent Inhibitor Selectively Targeting the Autophosphorylation Site of c-Src Kinase. ACS Chem Biol. 2024;19(4):999-1010. [Content Brief]

Calculators

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

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100 mg

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