ROS-IN-1
Based on 1 Customer Validation
ROS-IN-1 is a mitochondrial ROS inhibitor. ROS-IN-1 can reduce oxidative stress or inhibit reactive oxygen species (ROS) production.
For research use only. We do not sell to patients.
- Purity : 98.87%
- CAS No.: 298193-11-0
- Formula: C13H17NO3S
- Molecular Weight:267.34
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Storage:
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Protocols
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
In Vitro
ROS-IN-1 (Compound 40) can reduce ROS production (25.1%)[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
Chemical Information
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CAS No. 298193-11-0
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Appearance Solid
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Molecular Weight 267.34
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Formula C13H17NO3S
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Color White to off-white
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SMILES
O=C1N(S(=O)(C2=C(C)C=C(C)C=C2C)=O)CCC1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Solvent & Solubility
In Vitro:
DMSO : 100 mg/mL (374.06 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Protocols
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ROS/oxidative-stress fluorescent staining
ROS/oxidative-stress fluorescent staining uses cell-permeant fluorogenic probes that become fluorescent after oxidation inside cells or tissues; commonly used examples include DCFH-DA/DCFDA for broad cellular oxidant detection, DHE for superoxide-related signal detection, MitoSOX for mitochondrial superoxide-related signal detection, and CellROX probes for oxidative-stress-associated fluorescence readouts. The assay detects probe oxidation rather than a single ROS species unless the probe and analysis method have been chemically validated for that species. DCFH-DA enters cells, is deacetylated by intracellular esterases to DCFH, and produces fluorescent DCF after oxidation, so the readout is used as an operational measure of total cellular oxidative stress rather than a species-specific ROS measurement. DHE and MitoSOX can report superoxide-related oxidation, but red fluorescence alone can include non-specific ethidium-like oxidation products; HPLC or optimized spectral approaches are
Purity & Documentation
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Data Sheet (275 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.7406 mL | 18.7028 mL | 37.4056 mL | 93.5139 mL |
| 5 mM | 0.7481 mL | 3.7406 mL | 7.4811 mL | 18.7028 mL | |
| 10 mM | 0.3741 mL | 1.8703 mL | 3.7406 mL | 9.3514 mL | |
| 15 mM | 0.2494 mL | 1.2469 mL | 2.4937 mL | 6.2343 mL | |
| 20 mM | 0.1870 mL | 0.9351 mL | 1.8703 mL | 4.6757 mL | |
| 25 mM | 0.1496 mL | 0.7481 mL | 1.4962 mL | 3.7406 mL | |
| 30 mM | 0.1247 mL | 0.6234 mL | 1.2469 mL | 3.1171 mL | |
| 40 mM | 0.0935 mL | 0.4676 mL | 0.9351 mL | 2.3378 mL | |
| 50 mM | 0.0748 mL | 0.3741 mL | 0.7481 mL | 1.8703 mL | |
| 60 mM | 0.0623 mL | 0.3117 mL | 0.6234 mL | 1.5586 mL | |
| 80 mM | 0.0468 mL | 0.2338 mL | 0.4676 mL | 1.1689 mL | |
| 100 mM | 0.0374 mL | 0.1870 mL | 0.3741 mL | 0.9351 mL |
ROS-IN-1 Related Classifications
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