2. Neuronal Signaling
  3. Dopamine Transporter
  4. RTI 336

RTI 336 is a phenyltropane analog, as well as a potent and selective dopamine transporter (DAT) inhibitor. RTI 336 inhibits addictive agent induced locomotor activity and self-administration in Lewis rats. RTI 336 exhibits inhibitory effects depending on inherent NAc DAT levels.

For research use only. We do not sell to patients.

RTI 336 Chemical Structure

RTI 336 Chemical Structure

CAS No. : 204069-50-1

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RTI 336 Related Antibodies

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Description

RTI 336 is a phenyltropane analog, as well as a potent and selective dopamine transporter (DAT) inhibitor. RTI 336 inhibits addictive agent induced locomotor activity and self-administration in Lewis rats. RTI 336 exhibits inhibitory effects depending on inherent NAc DAT levels[1].

In Vivo

RTI 336 (3 mg/kg; sc; 30 min pretreatment) significantly decreases the number of infusions of addictive agent in Lewis rats[1].
RTI 336 (3 mg/kg; ip; 30 min pretreatment) decreases response rates (lever presses/s) induced by addictive agent in Lewis rats[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial
Molecular Weight

429.38

Formula

C24H26Cl2N2O
CAS No.
SMILES

CN1[C@H]2[C@@H](C3=CC(C4=CC=C(C)C=C4)=NO3)[C@@H](C5=CC=C(Cl)C=C5)C[C@@H]1CC2.Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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RTI 336 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

RTI 336204069-50-1RTI336RTI-336Dopamine TransporterDATSLC6A3Inhibitorinhibitorinhibit

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