2. Membrane Transporter/Ion Channel
  3. Potassium Channel
  4. RU-TRAAK-2

RU-TRAAK-2 is a completely reversible TRAAK (TWIK-related arachidonic acid-stimulated K+ channel) inhibitor. RU-TRAAK-2 exerts no activity for non-K2P channels (Kv1.2, Slo1 and GIRK2). RU-TRAAK-2 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

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RU-TRAAK-2 Chemical Structure

RU-TRAAK-2 Chemical Structure

CAS No. : 1210538-56-9

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5 mg USD 320 In-stock
10 mg USD 520 In-stock
25 mg USD 990 In-stock
50 mg USD 1650 In-stock
100 mg USD 2650 In-stock
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Based on 1 publication(s) in Google Scholar

RU-TRAAK-2 Related Antibodies

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Description

RU-TRAAK-2 is a completely reversible TRAAK (TWIK-related arachidonic acid-stimulated K+ channel) inhibitor. RU-TRAAK-2 exerts no activity for non-K2P channels (Kv1.2, Slo1 and GIRK2)[1]. RU-TRAAK-2 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

Molecular Weight

335.42

Formula

C19H17N3OS
CAS No.
Appearance

Solid

Color

White to yellow

SMILES

O=C(NCC#CC1=CC=CC=C1)N(CC2=NC3=CC=CC=C3S2)C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (149.07 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.9813 mL 14.9067 mL 29.8134 mL
5 mM 0.5963 mL 2.9813 mL 5.9627 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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C2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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g

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.72%

COA (246 KB) HNMR (264 KB) LCMS (266 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.9813 mL 14.9067 mL 29.8134 mL 74.5334 mL
5 mM 0.5963 mL 2.9813 mL 5.9627 mL 14.9067 mL
10 mM 0.2981 mL 1.4907 mL 2.9813 mL 7.4533 mL
15 mM 0.1988 mL 0.9938 mL 1.9876 mL 4.9689 mL
20 mM 0.1491 mL 0.7453 mL 1.4907 mL 3.7267 mL
25 mM 0.1193 mL 0.5963 mL 1.1925 mL 2.9813 mL
30 mM 0.0994 mL 0.4969 mL 0.9938 mL 2.4844 mL
40 mM 0.0745 mL 0.3727 mL 0.7453 mL 1.8633 mL
50 mM 0.0596 mL 0.2981 mL 0.5963 mL 1.4907 mL
60 mM 0.0497 mL 0.2484 mL 0.4969 mL 1.2422 mL
80 mM 0.0373 mL 0.1863 mL 0.3727 mL 0.9317 mL
100 mM 0.0298 mL 0.1491 mL 0.2981 mL 0.7453 mL
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RU-TRAAK-2 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

RU-TRAAK-21210538-56-9Potassium ChannelKcsAreversibleTRAAK non-K2PchannelsInhibitorinhibitorinhibit

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