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Cat. No.: HY-144383

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RXR antagonist 2

RXR antagonist 2 (compound 6b) is a potent antagonist of RXR with a K_i and K_d of 0.391 and 0.281 μM. RXR antagonist 2 has the potential for the research of RXR related diseases.

For research use only. We do not sell to patients.

CAS No.: 3010910-41-2
Formula: C₂₉H₃₅F₃N₂O₃
Molecular Weight:516.60

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (273 KB)

RXR antagonist 2 Chemical Structure

CAS No.: 3010910-41-2

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity

Description

RXR antagonist 2 (compound 6b) is a potent antagonist of RXR with a K_i and K_d of 0.391 and 0.281 μM. RXR antagonist 2 has the potential for the research of RXR related diseases^[1].

All RAR/RXR Isoforms :

Chemical Information

CAS No. 3010910-41-2
Molecular Weight 516.60
Formula C₂₉H₃₅F₃N₂O₃
SMILES

FC(F)(F)C1=NC2=C(C=CC(C(O)=O)=C2)N1C3=CC(C(C)(CCC4(C)C)C)=C4C=C3OCCCCCC
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (273 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Watanabe M, et al. Increased Molecular Flexibility Widens the Gap between Ki and Kd values in Screening for Retinoid X Receptor Modulators. ACS Med Chem Lett. 2022 Jan 21;13(2):211-217. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biological Activity
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Chemical Information
Purity & Documentation
References

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RXR antagonist 2

All RAR/RXR Isoforms