(S)-IP-DK143
(S)-IP-DK143 is a polymeric micellar formulation. (S)-IP-DK143 inhibits the proliferation of cervical cancer cells, induces ROS-mediated apoptosis, and triggers mitochondrial dysfunction. (S)-IP-DK143 activates the p38 MAPK signaling pathway, increases the phosphorylation level of p38. (S)-IP-DK143 can be used for the research of cervical cancer.
For research use only. We do not sell to patients.
- Formula: C31H34O6
- Molecular Weight:502.60
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
(S)-IP-DK143 (DK143) (1-100 μM; 24 h) potently inhibits the proliferation of HeLa cells, with an IC50 of 20.60 μM, and induces apoptotic morphological changes[1].
(S)-IP-DK143 (30 μM; 24 h) induces significant mitochondrial fission in HeLa cells, reducing mitochondrial length to 17.39% of that in the untreated group[1].
(S)-IP-DK143 (1-30 μM; 24 h) activates the p38 MAPK signaling pathway in HeLa cells, increasing the phosphorylation level of p38 to 398.9% of that in the untreated group, while slightly reducing the phosphorylation level of ERK[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:HeLa cervical cancer cells
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Concentration:0, 1, 3, 10, 30, and 100 μM
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Incubation Time:24 h
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Result:Induced concentration-dependent reduction in cell viability, with an IC50 value of 20.60 μM.
Displayed apoptotic morphological features including cell shrinkage, rounding, and detachment from the culture surface.
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Cell Line:HeLa cervical cancer cells
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Concentration:0, 1, 3 and 30 μM
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Incubation Time:24 h
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Result:Significantly increased p38 phosphorylation to 398.9% relative to the untreated control (with total p38 levels unchanged) at 30 μM.
Slightly reduced ERK phosphorylation.
Chemical Information
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Molecular Weight 502.60
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Formula C31H34O6
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SMILES
O=C([C@@H](C)C1=CC=C(CC(C)C)C=C1)OC2=C(C(/C=C/C3=CC=CC(OC)=C3OC)=O)C=C(OC)C=C2
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
(S)-IP-DK143 Related Classifications
HY-181817 Related Classifications
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