2. Immunology/Inflammation NF-κB Metabolic Enzyme/Protease Apoptosis MAPK/ERK Pathway Cell Cycle/DNA Damage
  3. Reactive Oxygen Species (ROS) Apoptosis p38 MAPK PERK
  4. (S)-IP-DK143

(S)-IP-DK143 is a polymeric micellar formulation. (S)-IP-DK143 inhibits the proliferation of cervical cancer cells, induces ROS-mediated apoptosis, and triggers mitochondrial dysfunction. (S)-IP-DK143 activates the p38 MAPK signaling pathway, increases the phosphorylation level of p38. (S)-IP-DK143 can be used for the research of cervical cancer.

For research use only. We do not sell to patients.

(S)-IP-DK143

(S)-IP-DK143 Chemical Structure

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(S)-IP-DK143 Related Antibodies

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Description

(S)-IP-DK143 is a polymeric micellar formulation. (S)-IP-DK143 inhibits the proliferation of cervical cancer cells, induces ROS-mediated apoptosis, and triggers mitochondrial dysfunction. (S)-IP-DK143 activates the p38 MAPK signaling pathway, increases the phosphorylation level of p38. (S)-IP-DK143 can be used for the research of cervical cancer[1].

In Vitro

(S)-IP-DK143 (DK143) (1-100 μM; 24 h) potently inhibits the proliferation of HeLa cells, with an IC50 of 20.60 μM, and induces apoptotic morphological changes[1].
(S)-IP-DK143 (30 μM; 24 h) induces significant mitochondrial fission in HeLa cells, reducing mitochondrial length to 17.39% of that in the untreated group[1].
(S)-IP-DK143 (1-30 μM; 24 h) activates the p38 MAPK signaling pathway in HeLa cells, increasing the phosphorylation level of p38 to 398.9% of that in the untreated group, while slightly reducing the phosphorylation level of ERK[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

(S)-IP-DK143 Related Antibodies

Cell Cytotoxicity Assay[1]

Cell Line: HeLa cervical cancer cells
Concentration: 0, 1, 3, 10, 30, and 100 μM
Incubation Time: 24 h
Result: Induced concentration-dependent reduction in cell viability, with an IC50 value of 20.60 μM.
Displayed apoptotic morphological features including cell shrinkage, rounding, and detachment from the culture surface.

Western Blot Analysis[1]

Cell Line: HeLa cervical cancer cells
Concentration: 0, 1, 3 and 30 μM
Incubation Time: 24 h
Result: Significantly increased p38 phosphorylation to 398.9% relative to the untreated control (with total p38 levels unchanged) at 30 μM.
Slightly reduced ERK phosphorylation.
Molecular Weight

502.60

Formula

C31H34O6
SMILES

O=C([C@@H](C)C1=CC=C(CC(C)C)C=C1)OC2=C(C(/C=C/C3=CC=CC(OC)=C3OC)=O)C=C(OC)C=C2
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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(S)-IP-DK143 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(S)-IP-DK143Reactive Oxygen Species (ROS)Apoptosisp38 MAPKPERKProtein kinase R-like endoplasmic reticulum kinasePKR-like endoplasmic reticulum kinasepolymeric micellar formulationInhibitorinhibitorinhibit

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