Bioactive Compound Library Plus
Based on 125 publication(s) in Google Scholar
Bioactive compounds are a general term for a class of substances that can cause certain biological effects in the body, which are the main source of small molecule drugs. These compounds generally penetrate cell membranes, act on specific target proteins in cells, regulate intracellular signaling pathways, and cause some changes in cell phenotype.
MCE owns a unique collection of 32,925 compounds with confirmed biological activities and clear targets. These compounds include natural products, innovative compounds, approved compounds, and clinical compounds. This library is a useful tool for signal pathway research, drug discovery and drug repurposing, etc.
Bioactive Compound Library Plus, with more powerful screening capability, further complements Bioactive Compound Library (HY-L001) by adding some compounds with low solubility or solution stability (Part B) and some novel, rare or exclusive compounds (Part C) to this library. Overall, bioactive compound library plus (HY-L001P) includes tree parts: Part A, Part B and Part C. Compounds in Part A are equal to the products in HY-L001, which can be supplied in solution or solid form. Compounds in Part B and C are only supplied in solid form.
For pre-dissolved solutions, 10 mM for compounds with the solubility not lower than 10 mM, 2 mM for compounds with solubility between 2 mM and 10 mM, and 3 mg/mL for compounds with unconfirmed molecular weight and solubility not lower than 3 mg/mL.
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Description & Advantages
• Bioactivity and safety confirmed by preclinical research and clinical trials. Some have been approved by FDA.
• Widely used in the research focus areas such as Cancer, Stem Cell, Neuronal Signaling, Immunity, and more.
• Structurally diverse, medicinally active, and cell permeable.
• More detailed compound information with structure, IC50, and other chemical & biological data.
• NMR and HPLC validated to ensure high purity and quality.
• All compounds are in stock and continuously updated.
| Part A | Part B | Part C | |
|---|---|---|---|
| Number | 26377 | 3155 | 3393 |
| Feature | General compounds (HY-L001) | Compounds with low solubility or stability | Novel, rare or exclusive compounds |
| Package | Solution (10 mM) or solid (1 mg) | Only solid (1 mg) | Only solid (1 mg) |
Product Details
A collection of 32,925 bioactive compounds supplied as pre-dissolved Solutions or Solid
Solution: 25,597 compounds supplied in 10 mM solution, 697 compounds supplied in 2 mM solution, 83 compounds supplied in 3 mg/mL solution.
96-well storage tube or 96-well plate: 1st and 12th column are left empty.
384-well plate: the first two columns and the last two columns are left empty.
Compounds with different concentrations or dissolved in different solvents will be put on separate plates.
This way of layout may increase the number of plates because there could be three solvents and three concentrations.
If you have other requirements, please let us know.
96- or 384-well Plate with Peelable Foil Seal; 96-well Format Sample Storage Tube With Screw Cap and Optional 2D Barcode
Publications (125)
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Journal Impact Factor
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Most Recent
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Chem Rev
2020 Oct 28;120(20):11616-11650. PMID: 32930577 -
Signal Transduct Target Ther
Z-DNA-binding protein 1 exacerbates myocardial ischemia‒reperfusion injury by inducing noncanonical cardiomyocyte PANoptosis. [Abstract]2025 Oct 7;10(1):333. PMID: 41052986 -
Signal Transduct Target Ther
Selective depletion of tumor-associated SAMHD1 enhances chemotherapeutic efficacy and antitumor immune responses. [Abstract]2025 Dec 15;10(1):406. PMID: 41392286 -
Nat Med
2017 Apr 7;23(4):405-408. PMID: 28388612 -
Circulation
Novel CaMKII-δ Inhibitor Hesperadin Exerts Dual Functions to Ameliorate Cardiac Ischemia/Reperfusion Injury and Inhibit Tumor Growth. [Abstract]2022 Apr 12;145(15):1154-1168. PMID: 35317609 -
Nat Methods
High-throughput profiling of chemical-induced gene expression across 93,644 perturbations. [Abstract]2025 Sep;22(9):1954-1963. PMID: 40826206 -
Nat Methods
2025 Oct;22(10):2028-2031. PMID: 40954295 -
Nat Metab
In vivo screen identifies a SIK inhibitor that induces β cell proliferation through a transient UPR. [Abstract]2021 May;3(5):682-700. PMID: 34031592 -
Mol Cell
2025 Jul 3;85(13):2581-2596.e6. PMID: 40555234 -
Nat Commun
Targeting leucine-rich repeat kinase 2 overcomes resistance to oncolytic herpes simplex virus-based therapies in glioblastoma. [Abstract]2026 Feb 28;17(1):3324. PMID: 41764166 -
Nat Commun
Correction of the molecular phenotype of X-linked Dystonia-Parkinsonism reveals a non-canonical function of BRD4. [Abstract]2026 May 5;17(1):4062. PMID: 42086561 -
Nat Commun
2025 Nov 13;16(1):9860. PMID: 41233320 -
Nat Commun
Both Boceprevir and GC376 efficaciously inhibit SARS-CoV-2 by targeting its main protease. [Abstract]2020 Sep 4;11(1):4417. PMID: 32887884 -
Nat Commun
Dysregulation of mitochondrial dynamics proteins are a targetable feature of human tumors. [Abstract]2018 Apr 26;9(1):1677. PMID: 29700304 -
Sci Transl Med
Acarbose ameliorates podocyte injury and glomerular lesions in diabetic nephropathy through USP46 activation. [Abstract]2026 Mar 11;18(840):eads4585. PMID: 41811985 -
Acta Pharm Sin B
Chrysin serves as a novel inhibitor of DGK α/FAK interaction to suppress the malignancy of esophageal squamous cell carcinoma (ESCC). [Abstract]2021 Jan;11(1):143-155. PMID: 33532186 -
Adv Sci (Weinh)
Gut Bacterium Lysinibacillus Sphaericus Exacerbates Aspirin-induced Intestinal Injury by Production of Carboxylesterase EstB. [Abstract]2025 Dec 12:e17747. PMID: 41387308 -
J Adv Res
LTX-315 is a novel broad-spectrum antimicrobial peptide against clinical multidrug-resistant bacteria. [Abstract]2025 Jan 9:S2090-1232(24)00621-0. PMID: 39793961 -
Protein Cell
2022 Sep 28;14(1):17-27. PMID: 36726755 -
Sci Adv
Quantitative prediction of siRNA complexation by ionizable drugs enables their codelivery in nanoparticles. [Abstract]2026 Jun 12;12(24):eaed2731. PMID: 42284421 -
J Biomed Sci
STAT3 exacerbates survival of cancer stem-like tumorspheres in EGFR-positive colorectal cancers: RNAseq analysis and therapeutic screening. [Abstract]2018 Aug 2;25(1):60. PMID: 30068339 -
Arthritis Rheumatol
Deficiency of cartilage-specific Y-box binding protein 1 represses NF-κB signaling and alleviates osteoarthritis progression. [Abstract]2025 Jul 14. PMID: 40654155 -
Cell Rep Med
RSAD2: A pathogenic interferon-stimulated gene at the maternal-fetal interface of patients with systemic lupus erythematosus. [Abstract]2025 Mar 18;6(3):101974. PMID: 39983716 -
Cancer Lett
2026 Apr 1:642:218300. PMID: 41651400 -
Proc Natl Acad Sci U S A
CRISPR screens identify the ATPase VCP as a druggable therapeutic vulnerability in cholangiocarcinoma. [Abstract]2025 Sep 30;122(39):e2519568122. PMID: 40991439 -
J Pharm Anal
DTLCDR: A target-based multimodal fusion deep learning framework for cancer drug response prediction. [Abstract]2025 Aug;15(8):101315. PMID: 41050110 -
Phytomedicine
Unveiling poliumoside: A herbal-derived FAK kinase inhibitor with anti-proliferative and anti-metastatic efficacy. [Abstract]2025 Dec 30:150:157747. PMID: 41485292 -
EMBO Mol Med
In vitro and in vivo drug screens of tumor cells identify novel therapies for high-risk child cancer. [Abstract]2022 Apr 7;14(4):e14608. PMID: 34927798 -
NPJ Precis Oncol
METTL21A promotes hepatocellular carcinoma progression via methylating and stabilizing BAG3. [Abstract]2025 Jul 10;9(1):234. PMID: 40640484 -
Cell Syst
A Library of Phosphoproteomic and Chromatin Signatures for Characterizing Cellular Responses to Drug Perturbations. [Abstract]2018 Apr 25;6(4):424-443.e7. PMID: 29655704 -
Emerg Microbes Infect
AMXT-1501 targets membrane phospholipids against Gram-positive and -negative multidrug-resistant bacteria. [Abstract]2024 Dec;13(1):2321981. PMID: 38422452 -
Emerg Microbes Infect
A novel transcription and replication-competent virus-like particles system modelling the Nipah virus life cycle. [Abstract]2024 Jun 12:2368217. PMID: 38865205 -
Cell Chem Biol
An engineered cysteine sensor optimized for high-throughput screening identifies regulators of intracellular thiol levels. [Abstract]2025 Nov 20;32(11):1381-1396.e8. PMID: 41218609 -
Cell Chem Biol
In vivo drug discovery for increasing incretin-expressing cells identifies DYRK inhibitors that reinforce the enteroendocrine system. [Abstract]2022 Sep 15;29(9):1368-1380.e5. PMID: 35998625 -
Cell Death Discov
2023 Dec 1;9(1):435. PMID: 38040674 -
Cell Rep
A Landscape of Therapeutic Cooperativity in KRAS Mutant Cancers Reveals Principles for Controlling Tumor Evolution. [Abstract]2017 Jul 25;20(4):999-1015. PMID: 28746882 -
Clin Transl Med
Functional genomics pipeline identifies CRL4 inhibition for the treatment of ovarian cancer. [Abstract]2025 Feb;15(2):e70078. PMID: 39856363 -
J Med Chem
From Experiments to a Fast Easy-to-Use Computational Methodology to Predict Human Aldehyde Oxidase Selectivity and Metabolic Reactions. [Abstract]2018 Jan 11;61(1):360-371. PMID: 29240409 -
Anal Chem
Longitudinal Fragment Profiles Based on Multi-Collision Energy Tandem Mass Spectra Improve the Accuracy of Metabolite Identification in Untargeted Metabolomics. [Abstract]2025 Jul 15;97(27):14349-14360. PMID: 40592760 -
J Anim Sci Biotechnol
Unveiling the emerging role of curcumin to alleviate ochratoxin A-induced muscle toxicity in grass carp (Ctenopharyngodon idella): in vitro and in vivo studies. [Abstract]2024 May 12;15(1):72. PMID: 38734645 -
J Agric Food Chem
FK506 Targets MoFpr1 to Modulate Autophagy and Ubiquitination, Inhibiting the Pathogenicity of Magnaporthe oryzae. [Abstract]2025 Jun 18;73(24):14985-15002. PMID: 40490869 -
Eur J Med Chem
2019 Feb 1:163:169-182. PMID: 30508666 -
Chin Med
A new paradigm for drug discovery in the treatment of complex diseases: drug discovery and optimization. [Abstract]2025 Mar 24;20(1):40. PMID: 40122800 -
J Invest Dermatol
Combined Cyclin-Dependent Kinase Inhibition Overcomes MAPK/Extracellular Signal-Regulated Kinase Kinase Inhibitor Resistance in Plexiform Neurofibroma of Neurofibromatosis Type I. [Abstract]2022 Mar;142(3 Pt A):613-623.e7. PMID: 34534577 -
J Cheminform
HAMdb: a database of human autophagy modulators with specific pathway and disease information. [Abstract]2018 Jul 31;10(1):34. PMID: 30066211 -
Biochem Pharmacol
2025 Jan 21:116765. PMID: 39848475 -
Biochem Pharmacol
Givinostat rescues folding of cystathionine beta-synthase and ameliorates murine homocystinuria. [Abstract]2025 Jun 24:239:117079. PMID: 40571220 -
Biochem Pharmacol
High-throughput screening as a drug repurposing strategy for poor outcome subgroups of pediatric B-cell precursor Acute Lymphoblastic Leukemia. [Abstract]2023 Nov:217:115809. PMID: 37717691 -
J Chem Inf Model
2025 Jun 9;65(11):5718-5729. PMID: 40366258 -
Life Sci
Identification of novel CDK 9 inhibitors based on virtual screening, molecular dynamics simulation, and biological evaluation. [Abstract]2020 Oct 1;258:118228. PMID: 32781071 -
Expert Opin Drug Discov
2025 Dec;20(12):1589-1606. PMID: 41354464 -
Front Pharmacol
CC-223, NSC781406, and BGT226 Exerts a Cytotoxic Effect Against Pancreatic Cancer Cells via mTOR Signaling. [Abstract]2020 Nov 11;11:580407. PMID: 33343350 -
Bioorg Chem
Discovery of novel TLR4/MD-2 inhibitors: Receptor structure-based virtual screening studies and anti-inflammatory evaluation. [Abstract]2023 Dec:141:106880. PMID: 37783098 -
Nanomedicine
Improving lipid nanoparticles delivery efficiency of macrophage cells by using immunomodulatory small molecules. [Abstract]2025 Feb 3:64:102809. PMID: 39904398 -
RSC Adv
MedChemExpress compounds prevent neuraminidase N1 via physics- and knowledge-based methods. [Abstract]2024 Jun 12;14(27):18950-18956. PMID: 38873542 -
Int J Antimicrob Agents
Immunomodulator AS101 restores colistin susceptibility of clinical colistin-resistant Escherichia coli and Klebsiella pneumoniae in vitro and in vivo. [Abstract]2024 Aug 5:107285. PMID: 39111708 -
J Med Virol
Inhibitory effect on SARS-CoV-2 infection of neferine by blocking Ca2+ -dependent membrane fusion. [Abstract]2021 Oct;93(10):5825-5832. PMID: 34061377 -
Cell Rep Methods
A fluorescent STING ligand sensor for high-throughput screening of compounds that can enhance tumor immunotherapy. [Abstract]2025 Jul 21;5(7):101106. PMID: 40669456 -
ACS Omega
2024 Feb 5;9(6):6059-6073. PMID: 38371787 -
Biochim Biophys Acta Mol Basis Dis
Neutrophil-derived thrombospondin-1 (THBS1) drives type 2 diabetes-induced osteoporosis via CD36-PPARγ-POU2F2 signaling. [Abstract]2025 Dec 15;1872(3):168139. PMID: 41407214 -
iScience
A combined AI and cell biology approach surfaces targets and mechanistically distinct Inflammasome inhibitors. [Abstract]2024 Nov 16;27(12):111404. PMID: 39687021 -
iScience
Molecular mechanism of a triazole-containing inhibitor of Mycobacterium tuberculosis DNA gyrase. [Abstract]2024 Sep 16;27(10):110967. PMID: 39429773 -
ACS Med Chem Lett
Serial PNA-Transformer-Based Virtual Screening Identifies Nanomolar DYRK1A Inhibitors for Pancreatic Ductal Adenocarcinoma. [Abstract]2026 Feb 20;17(3):695-703. PMID: 41847637 -
Sci Rep
Structure-based identification of compounds with potential as selective BLT1 antagonists. [Abstract]2025 Dec 11. PMID: 41381763 -
J Biol Chem
Identification of small molecules and related targets that modulate tau pathology in a seeded primary neuron model. [Abstract]2023 Jul;299(7):104876. PMID: 37269953 -
Sci Rep
Unveiling some FDA-approved drugs as inhibitors of the store-operated Ca2+ entry pathway. [Abstract]2017 Oct 16;7(1):12881. PMID: 29038464 -
ACS Infect Dis
Repurposing GSK2018682 Confers Dual Antibacterial and Antibiofilm Activity against Staphylococcus aureus. [Abstract]2026 Feb 13;12(2):623-636. PMID: 41525229 -
Chem Res Toxicol
Predicting the Mitochondrial Toxicity of Small Molecules: Insights from Mechanistic Assays and Cell Painting Data. [Abstract]2023 Jul 17;36(7):1107-1120. PMID: 37409673 -
Microbiol Spectr
Potential quorum-sensing inhibitor of Hafnia alvei H4-theaflavin-3,3´-digallate analyzed by virtual screening and molecular simulation. [Abstract]2023 Sep 21;11(5):e0267123. PMID: 37732782 -
ACS Chem Biol
Chemical Proteomics and Structural Biology Define EPHA2 Inhibition by Clinical Kinase Drugs. [Abstract]2016 Dec 16;11(12):3400-3411. PMID: 27768280 -
ACS Chem Biol
2016 May 20;11(5):1245-54. PMID: 26863403 -
Biology (Basel)
Silk Gland Factor 1 Plays a Pivotal Role in Larval Settlement of the Fouling Mussel Mytilopsis sallei. [Abstract]2024 Jun 5;13(6):417. PMID: 38927297 -
Epigenetics Chromatin
2020 Aug 3;13(1):31. PMID: 32746900 -
Toxicol Appl Pharmacol
Drug screening reveals the mechanism of toyocamycin-induced apoptosis in triple-negative breast cancer organoids. [Abstract]2026 Jan:506:117659. PMID: 41314261 -
J Comput Aided Mol Des
Synergistic approach utilizing bioinformatics, machine learning, and traditional screening for the identification of novel CSK inhibitors targeting hepatocellular carcinoma. [Abstract]2025 Nov 8;39(2):119. PMID: 41204015 -
ChemistryOpen
Discovery of Potential GPRC5D Inhibitors through Virtual Screening and Molecular Dynamics Simulations. [Abstract]2025 Sep 7:e202500360. PMID: 40914945 -
Bioorg Med Chem
Identification of a novel Aurora B inhibitor using the AI-driven drug screening and docking-based traditional screening. [Abstract]2025 Sep 27:131:118423. PMID: 41033076 -
Biol Reprod
Strong inhibition of neutrophil-sperm interaction in cattle by selective phosphatidylinositol 3-kinase inhibitors. [Abstract]2017 Nov 1;97(5):671-687. PMID: 29036279 -
SLAS Discov
An MRC-5 cell based high-throughput, high-content imaging assay to identify hits against Trypanosoma cruzi intracellular parasites. [Abstract]2026 Feb 17:39:100298. PMID: 41713554 -
J Am Soc Mass Spectrom
2026 Jan 7;37(1):8-12. PMID: 41324382 -
SLAS Discov
Corelet™ platform: Precision high throughput screening for targeted drug discovery of biomolecular condensates. [Abstract]2025 Apr:32:100224. PMID: 40024444 -
SLAS Discov
2020 Sep;25(8):895-905. PMID: 32567455 -
J Antibiot (Tokyo)
Design, synthesis, and antibacterial evaluation of novel derivatives of NPS-2143 for the treatment of methicillin-resistant S. aureus (MRSA) infection. [Abstract]2019 Jul;72(7):545-554. PMID: 30940910 -
PLoS One
Antibiofilm and antibacterial activity of maslinic acid against Vancomycin-Resistant Enterococci (VRE). [Abstract]2026 Feb 10;21(2):e0342234. PMID: 41666236 -
J Nat Med
2025 May;79(3):441-464. PMID: 39979670 -
Mem Inst Oswaldo Cruz
2022 Mar 11:117:e210402. PMID: 35293482 -
Virology
CX-6258 hydrochloride hydrate: A potential non-nucleoside inhibitor targeting the RNA-dependent RNA polymerase of norovirus. [Abstract]2024 Jul:595:110088. PMID: 38643657 -
Biochem Biophys Res Commun
Effects of intracellular iron overload on cell death and identification of potent cell death inhibitors. [Abstract]2018 Sep 3;503(1):297-303. PMID: 29890135 -
Biochem Biophys Res Commun
Effects of intracellular iron overload on cell death and identification of potent cell death inhibitors. [Abstract]2018 Sep 3;503(1):297-303. PMID: 29890135 -
Reprod Biol
Novel screening approach for stem cell selective inhibitors and their possible translational therapeutic potential for endometriosis. [Abstract]2025 Jan 11;25(1):100992. PMID: 39799809 -
FASEB Bioadv
Inhibition of the HEG1-KRIT1 interaction increases KLF4 and KLF2 expression in endothelial cells. [Abstract]2021 Feb 18;3(5):334-355. PMID: 33977234 -
Biol Open
2026 Feb 15;15(2):bio062380. PMID: 41601273 -
In Vitro Cell Dev Biol Anim
The synergistic effect of 5Azadc and TSA on maintenance of pluripotency of chicken ESCs by overexpression of NANOG gene. [Abstract]2016 Apr;52(4):488-96. PMID: 26822431 -
bioRxiv
EGFR INHIBITION PROMOTES ENTEROENDOCRINE CELL DIFFERENTIATION CONTRIBUTING TO TREATMENT-ASSOCIATED DIARRHEA. [Abstract]2026 Jun 5:2026.06.02.729650. PMID: 42282735 -
bioRxiv
Discovery of pan-ErbB inhibitors protecting from SARS-CoV-2 replication, inflammation, and lung injury by a drug repurposing screen. [Abstract]2023 May 10:2021.05.15.444128. PMID: 34159337 -
Brief Bioinform
A novel framework integrating AI model and enzymological experiments promotes identification of SARS-CoV-2 3CL protease inhibitors and activity-based probe. [Abstract]2021 Nov 5;22(6):bbab301. PMID: 34368837 -
bioRxiv
Morphological Cell Profiling of SARS-CoV-2 Infection Identifies Drug Repurposing Candidates for COVID-19. [Abstract]2020 Dec 7:2020.05.27.117184. PMID: 32577649 -
Acta Med Iran
Precision Medicine Approach to Anaplastic Thyroid Cancer: Advances in Targeted Drug Therapy Based on Specific Signaling Pathways. [Abstract]2017 Mar;55(3):200-208. PMID: 28282720 -
J Biomol Screen
Multiparametric Phenotypic Screening System for Profiling Bioactive Compounds Using Human Fetal Hippocampal Neural Stem/Progenitor Cells. [Abstract]2015 Oct;20(9):1074-83. PMID: 26245650 -
Chem Biol
Systematic Mapping of Kinase Addiction Combinations in Breast Cancer Cells by Integrating Drug Sensitivity and Selectivity Profiles. [Abstract]2015 Aug 20;22(8):1144-55. PMID: 26211361
Documentation
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Composition
Apoptosis (3421)
Bacterial (2260)
Endogenous Metabolite (2031)
Autophagy (1259)
Environmental Pollutants (956)
Antibiotic (939)
MOFs (891)
DNA/RNA Synthesis (801)
NF-κB (747)
Parasite (740)
Fungal (696)
Drug Derivative (688)
Interleukin Related (606)
Akt (525)
PROTACs (515)
Drug Metabolite (514)
CDK (497)
5-HT Receptor (470)
Caspase (456)
PI3K (433)
p38 MAPK (429)
Adrenergic Receptor (412)
ERK (399)
COX (396)
Potassium Channel (394)
Calcium Channel (391)
Cytochrome P450 (381)
Epigenetic Reader Domain (354)
HIV (353)
EGFR (336)
STAT (331)
TNF Receptor (323)
Phosphodiesterase (PDE) (308)
Bcl-2 Family (306)
Dopamine Receptor (299)
SARS-CoV (299)
Liposome (295)
NO Synthase (282)
Phosphatase (282)
mTOR (266)
Ferroptosis (259)
iGluR (259)
MMP (258)
PPAR (257)
Estrogen Receptor/ERR (254)
HDAC (254)
Sodium Channel (252)
GABA Receptor (251)
JAK (251)
VEGFR (249)
Ras (246)
Histamine Receptor (244)
Toll-like Receptor (TLR) (244)
Mitochondrial Metabolism (238)
TRP Channel (234)
PARP (228)
Amyloid-β (224)
mAChR (224)
MDM-2/p53 (224)
Microtubule/Tubulin (224)
JNK (220)
Cholinesterase (ChE) (214)
Keap1-Nrf2 (214)
Wnt (208)
Influenza Virus (206)
Ligands for E3 Ligase (198)
AMPK (197)
Topoisomerase (190)
Prostaglandin Receptor (188)
PKC (176)
mGluR (173)
nAChR (168)
Integrin (166)
HSP (163)
Herbicide (160)
NOD-like Receptor (NLR) (160)
E1/E2/E3 Enzyme (158)
Androgen Receptor (155)
Drug Intermediate (152)
Drug Isomer (152)
Molecular Glues (152)
Opioid Receptor (150)
HCV (149)
GSK-3 (148)
Adenosine Receptor (147)
Monoamine Oxidase (142)
β-catenin (139)
Sirtuin (137)
Src (137)