DAMGO TFA
Based on 13 publication(s) in Google Scholar
DAMGO TFA is a μ-opioid receptor (μ-OPR ) selective agonist with a Kd of 3.46 nM for native μ-OPR.
For research use only. We do not sell to patients.
- Purity: 99.52%
- CAS No.: 950492-85-0
- Formula: C28H36F3N5O8
- Molecular Weight:627.61
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Storage:
Sealed storage, away from moisture.
Powder -80°C, 2 years , -20°C, 1 year* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Publications Citing Use of MedChemExpress (MCE) DAMGO TFA
More- Nature. 2026 Apr;652(8112):1393-1404. [Abstract]
- Nature. 2025 Dec;648(8094):755-763. [Abstract]
- Cell. 2026 Apr 30;189(9):2612-2632.e24. [Abstract]
- Cell. 2023 Jan 19;186(2):413-427.e17. [Abstract]
- Cell. 2022 Nov 10;185(23):4361-4375.e19. [Abstract]
- Brain. 2026 Feb 25:awag077. [Abstract]
- Alzheimers Res Ther. 2025 Feb 1;17(1):35. [Abstract]
- J Med Chem. 2026 Mar 5;69(6):6508-6527.
- Cell Rep Methods. 2025 May 19;5(5):101051. [Abstract]
- Aquaculture. 2025 Apr 15.
- Seoul National University. 2024 Feb.
- bioRxiv. 2024 Jul 26:2024.07.26.605282. [Abstract]
- bioRxiv. 2022 Jul 11.
Customer Validation & Images
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RT-PCR
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IF
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Bio/Physico-chemical Assay
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Bio/Physico-chemical Assay
All Opioid Receptor Isoforms
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Biological Activity
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μ Opioid Receptor/MOR |
DAMGO (1-10 μM) TFA significantly reduces the activation of neuronal Akt and ERK1/2 by CXCL12 and inhibits CXCL12-promoted neuronal survival, but does not down-regulate CXCR4 protein expression[2].
DAMGO (1 μM) TFA effectively inhibits the prostaglandin E 2 (PGE 2) induced increase in a tetrodotoxin-resistant voltage-gated Na+ current (TTX-R I Na), i.e. PGE 2 (1 μM) can increase the TTX-R I Na peak by 103 % compared to 24.9 % with the addition of DAMGO[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 950492-85-0
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Appearance Solid
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Molecular Weight 627.61
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Formula C28H36F3N5O8
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Color White to off-white
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Sequence
Tyr-{d-Ala}-Gly-{Me-Phe}-Gly-ol
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Sequence Shortening
Y-{d-Ala}-G-{Me-Phe}-G-ol
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Sealed storage, away from moisture
Powder -80°C 2 years -20°C 1 year * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Publications (13)
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Journal Impact Factor
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Most Recent
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Nature
2026 Apr;652(8112):1393-1404. PMID: 41922775 -
Nature
2025 Dec;648(8094):755-763. PMID: 41193810 -
Cell
Mechanism-guided identification of antidepressant G protein-coupled receptor drug targets. [Abstract]2026 Apr 30;189(9):2612-2632.e24. PMID: 42030928 -
Cell
2023 Jan 19;186(2):413-427.e17. PMID: 36638794 -
Cell
2022 Nov 10;185(23):4361-4375.e19. PMID: 36368306 -
Brain
2026 Feb 25:awag077. PMID: 41738433 -
Alzheimers Res Ther
Delta-opioid receptor signaling alleviates neuropathology and cognitive impairment in the mouse model of Alzheimer's disease by regulating microglia homeostasis and inhibiting HMGB1 pathway. [Abstract]2025 Feb 1;17(1):35. PMID: 39893485 -
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Cell Rep Methods
Profiling human iPSC-derived sensory neurons for analgesic drug screening using a multi-electrode array. [Abstract]2025 May 19;5(5):101051. PMID: 40367946 -
DAMGO TFA purchased from MedChemExpress. Usage Cited in: Aquaculture. 2025 Apr 15.
Transcript levels of agrp, drd1 and drd2 in glucose and DAMGO stimulation (20 μM; 24 h). DAMGO treatment eliminated the increased expression of drd2 induced by glucose stimulation.
DAMGO TFA purchased from MedChemExpress. Usage Cited in: Aquaculture. 2025 Apr 15.
Fluorescence levels of AgRP and c-Fos in glucose and DAMGO (20 μM) or SCK-39394 stimulation for 24 h. DAMGO treatment rescued the decreased immunoreactivity of Agrp and c-Fos proteins suppressed by glucose.
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DAMGO TFA purchased from MedChemExpress. Usage Cited in: Seoul National University. 2024 Feb.
The effect of DAMGO (0.1-1000 nM) on forskolin (3 μM)-induced cAMP production was measured using a GloSensor cAMP assay. DAMGO induced μOR activation and effectively inhibited forskolininduced cAMP production.
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bioRxiv
2024 Jul 26:2024.07.26.605282. PMID: 39091869
DAMGO TFA purchased from MedChemExpress. Usage Cited in: bioRxiv. 2024 Jul 26:2024.07.26.605282. [Abstract]
Representative kinetics of cAMP accumulation in response to agonist stimulation of indicated GPCRs using DAMGO (1 μM; 25 min). Application of DAMGO revealed a robust accumulation of intracellular cAMP as measured using a split-luciferase GloSensor.
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Solvent & Solubility
H2O : ≥ 100 mg/mL (159.33 mM)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
For the following dissolution methods, please prepare the working solution directly:
It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: PBS
Solubility: 100 mg/mL (159.33 mM); Clear solution; Need ultrasonic
Purity & Documentation
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Data Sheet (276 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
[1]. FEBS Lett. 1995 Jan 2;357(1):93-7. Onogi T, et al. DAMGO, a mu-opioid receptor selective agonist, distinguishes between mu- and delta-opioid receptors around their first extracellular loops. [Content Brief]
[2]. Patel JP, et al. Modulation of neuronal CXCR4 by the micro-opioid agonist DAMGO. J Neurovirol. 2006 Dec;12(6):492-500. [Content Brief]
[3]. Gold MS, et al. DAMGO inhibits prostaglandin E2-induced potentiation of a TTX-resistant Na+ current in rat sensory neurons in vitro. Neurosci Lett. 1996 Jul 12;212(2):83-6. [Content Brief]
[4]. Desmeules JA, et al. Selective opioid receptor agonists modulate mechanical allodynia in an animal model of neuropathic pain. Pain. 1993 Jun;53(3):277-285. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 1.5933 mL | 7.9667 mL | 15.9335 mL | 39.8337 mL |
| 5 mM | 0.3187 mL | 1.5933 mL | 3.1867 mL | 7.9667 mL | |
| 10 mM | 0.1593 mL | 0.7967 mL | 1.5933 mL | 3.9834 mL | |
| 15 mM | 0.1062 mL | 0.5311 mL | 1.0622 mL | 2.6556 mL | |
| 20 mM | 0.0797 mL | 0.3983 mL | 0.7967 mL | 1.9917 mL | |
| 25 mM | 0.0637 mL | 0.3187 mL | 0.6373 mL | 1.5933 mL | |
| 30 mM | 0.0531 mL | 0.2656 mL | 0.5311 mL | 1.3278 mL | |
| 40 mM | 0.0398 mL | 0.1992 mL | 0.3983 mL | 0.9958 mL | |
| 50 mM | 0.0319 mL | 0.1593 mL | 0.3187 mL | 0.7967 mL | |
| 60 mM | 0.0266 mL | 0.1328 mL | 0.2656 mL | 0.6639 mL | |
| 80 mM | 0.0199 mL | 0.0996 mL | 0.1992 mL | 0.4979 mL | |
| 100 mM | 0.0159 mL | 0.0797 mL | 0.1593 mL | 0.3983 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
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